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The Effect of Calcium on Postprandial Lipid Profile and Appetite

This study has been completed.
Arla Foods
The Danish Dairy Research Foundation, Denmark
FOOD Graduate School, the Royal Veterinary & Agricultural University, Denmark
Danish Research Agency
Dutch Dairy Organization (NZO)
Pharna Vinci, Denmark
Information provided by:
University of Copenhagen Identifier:
First received: April 19, 2007
Last updated: January 20, 2009
Last verified: December 2004
The purpose of this study is to investigate the effect of calcium on postprandial lipid profile and appetite.

Condition Intervention
Behavioral: high calcium intake

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Open Label

Resource links provided by NLM:

Further study details as provided by University of Copenhagen:

Primary Outcome Measures:
  • Postprandial changes in: total plasma triacylglyceride; Chylomicron triacylglyceride; Cholesterol

Secondary Outcome Measures:
  • Postprandial changes in:insulin; glucose; CCK; Ghrelin; GLP-1, appetite measured by visual analogue scales, BCAA

Estimated Enrollment: 18
Study Start Date: February 2005
Estimated Study Completion Date: October 2005
Detailed Description:

Several reports have found inverse associations between calcium intake and body weight. Intervention studies have shown that a high calcium diet resulted in a greater body weight loss than a low calcium diet. In addition, it seems that calcium from dairy products have a more profound effect than calcium from supplements. The mechanism of this additional dairy effect is not yet clear, but one possible explanation could be reduced absorption of fat in the gut. The increase in fecal fat excretion on a high calcium diet could be due to the formation of calcium-fatty acid soaps in the gut.

The long term effect of a high calcium intake have been under intense investigation, but as far as we know the acute effect of a high calcium intake have not yet been examined. A study concerning the acute effects could help us understand the effect of calcium on the absorption of fat. After a meal triglyceride (TG) is packaged with cholesterol, lipoproteins and other lipids into particles called chylomicrons. Earlier studies have shown that the fatty acid pattern of chylomicron lipids postprandial was very similar to that of the ingested fat. If we assume that calcium inhibits the absorption of fat, we would expect a reduced total plasma triglyceride concentration after a calcium-rich meal.

Appetite involves many different sensations among which hunger and satiety are the most investigated. Several different hormones are involved in the regulation of appetite. Some of these hormones are known to respond to the intake or absorption of fat. If the absorption of fat is inhibited the regulation of appetite most likely will be affected. In the long term this could be important because an increased appetite probably would increase energy intake and thereby reducing the weight loss we otherwise might have accomplished by the reduced absorption of fat.


Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy meals
  • BMI 24-31 kg/m2
  • age between 18-50 years
  • hemoglobin >8 mmol/L

Exclusion Criteria:

  • donation of blood 6 months before and under the study
  • milk allergy, diabetes, hypertension, hyperlipidemia, cronic infectious disease
  • use of dietary supplements 3 months before and under the study
  • smoking
  • elite athletes
  • use of medication
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Please refer to this study by its identifier: NCT00464035

Institute of Human Nutrition
Copenhagen, Denmark, 1958
Sponsors and Collaborators
University of Copenhagen
Arla Foods
The Danish Dairy Research Foundation, Denmark
FOOD Graduate School, the Royal Veterinary & Agricultural University, Denmark
Danish Research Agency
Dutch Dairy Organization (NZO)
Pharna Vinci, Denmark
Principal Investigator: Arne Astrup, Prof. Dr. Institute of Human Nutrition, the Royal Veterinary & Agricultural University, Denmark
  More Information Identifier: NCT00464035     History of Changes
Other Study ID Numbers: KF 01-144/02
Study First Received: April 19, 2007
Last Updated: January 20, 2009

Keywords provided by University of Copenhagen:
Fat absorption
Postprandial lipid profile

Additional relevant MeSH terms:
Calcium, Dietary
Bone Density Conservation Agents
Physiological Effects of Drugs processed this record on May 25, 2017