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Investigation of Correlation Between Interstitial and Arterial Blood Glucose Concentrations in Septic Patients

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ClinicalTrials.gov Identifier: NCT00463645
Recruitment Status : Completed
First Posted : April 20, 2007
Last Update Posted : June 6, 2007
Sponsor:
Information provided by:
Medical University of Graz

Brief Summary:
This is a mono-centre trial performed at the medical ICU at the Medical University Graz. There will be a study visit (V1) and a follow-up assessment (V2). In the study visit (V1) arterial blood glucose values will be monitored and subcutaneous sampling of interstitial fluid (ISF) with microdialysis for glucose determination and with microperfusion for cytokine-measurement will be performed. The study visit will last for 26 hours starting with the insertion of two catheters in the abdominal subcutaneous tissue (one microdialysis- and one microperfusion catheter). The primary hypothesis of the study is: Interstitial fluid glucose concentration profiles correlates to the arterial blood glucose concentration profile in patients with severe sepsis in the medical ICU.

Condition or disease Intervention/treatment
Severe Sepsis Procedure: microdialysis Procedure: microperfusion

Study Type : Observational
Enrollment : 10 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: An Open, Mono-Centre Trial to Investigate the Correlation Between the Interstitial and Arterial Blood Concentrations of Glucose During Subcutaneous Glucose Monitoring in Patients With Severe Sepsis at the Medical Intensive Care Unit
Study Start Date : September 2005
Actual Study Completion Date : January 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Sepsis





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Ages Eligible for Study:   18 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients in the medical ICU fulfilling criteria for severe sepsis
  • Mechanical ventilation
  • Increased blood glucose levels ( > 120 mg/dL; > 6.7 mM), or requiring insulin treatment.
  • Age of patients in the range from 18 to 90 years.

Exclusion Criteria:

  • Any disease or condition which the Investigator or the treating physician feels would interfere with the trial or the safety of the patient

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00463645


Locations
Austria
Medical University Graz
Graz, Styria, Austria, 8036
Sponsors and Collaborators
Medical University of Graz
Investigators
Principal Investigator: Thomas R. Pieber, MD. Medical University of Graz

Additional Information:
ClinicalTrials.gov Identifier: NCT00463645     History of Changes
Other Study ID Numbers: CM3_adipose
First Posted: April 20, 2007    Key Record Dates
Last Update Posted: June 6, 2007
Last Verified: April 2007

Additional relevant MeSH terms:
Sepsis
Infection
Systemic Inflammatory Response Syndrome
Inflammation
Pathologic Processes