Invasive Infections in Children With Hemoglobinopathies

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00456443
Recruitment Status : Completed
First Posted : April 5, 2007
Last Update Posted : April 5, 2007
Information provided by:
HaEmek Medical Center, Israel

Brief Summary:
Patients diagnosed as having hemoglobinopathies are exposed to serious bacterial infections, principally those patients that underwent splenectomy. Since the introduction of anti pneumococcal vaccine the incidence decreased significantly but other bacteria besides encapsulated bacteria takes place as principal cause of invasive infections. The purpose of this study is to analyse in a retrospective study the incidence of those infections in a group of patients suffering from thalassemia and sickle cell anemia treated in our clinic.

Condition or disease Intervention/treatment
Thalassemia Sickle Cell Anemia Procedure: Historical records

Study Type : Observational
Estimated Enrollment : 200 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Retrospective
Official Title: Invasive Infections in Children With Hemoglobinopathies. A Clinical Descriptive Retrospective Study.
Study Start Date : January 2006
Study Completion Date : June 2006

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Thalassemia
U.S. FDA Resources

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   up to 40 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • All patients treated in the Pediatric Hematology Unit.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00456443

Pediatric Hematology Unit and Pediatric Dpt B - HaEmek Medical Center
Afula, Israel, 18101
Sponsors and Collaborators
HaEmek Medical Center, Israel
Study Director: Ariel Koren, MD Pediatric Hematology Unit, Ha'Emek Medical Center
Principal Investigator: Waheeb Sakran, MD Pediatric Dpt B - Ha'Emek Medical Center Identifier: NCT00456443     History of Changes
Other Study ID Numbers: 4140905.EMC
First Posted: April 5, 2007    Key Record Dates
Last Update Posted: April 5, 2007
Last Verified: April 2007

Keywords provided by HaEmek Medical Center, Israel:
Sickle cell anemia
Streptococcal Pneumonia

Additional relevant MeSH terms:
Anemia, Sickle Cell
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
Hematologic Diseases
Genetic Diseases, Inborn