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Atorvastatin in Moderate Active Crohns Disease

This study has been completed.
Information provided by:
Skane University Hospital Identifier:
First received: March 29, 2007
Last updated: October 18, 2007
Last verified: October 2007
Open pilot study to collect information regarding the effect of atorvastatin on patients with active Crohns disease.

Condition Intervention Phase
Crohns Disease Drug: Atorvastatin Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Skane University Hospital:

Primary Outcome Measures:
  • Inflammatory markers in plasma before and after treatment.

Secondary Outcome Measures:
  • Change in clinical activity index and mucosal inflammation after treatment.

Estimated Enrollment: 12
Study Start Date: October 2006
Study Completion Date: October 2007

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Clinical diagnosis of Crohns disease
  • C-reactive protein level > 2 mg/L in absence of an infection
  • Fecal calprotectin > 250 mg/kg or CDAI > 150

Exclusion Criteria:

  • CDAI > 450
  • Prednisolone dosage above 15 mg/day
  Contacts and Locations
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Please refer to this study by its identifier: NCT00454545

Department of Medicine, Division of Gastroenterology and Hepatology
Malmö, Sweden, 20502 Malmö
Sponsors and Collaborators
Skane University Hospital
Principal Investigator: Olof Grip, MD, PhD Malmo University Hospital, Region Skåne
Study Chair: Anders Bredberg, MD, PhD Malmo University Hospital, Region Skåne
Study Chair: Gunnel Bredberg, MD, PhD Malmo University Hospital, Region Skåne
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00454545     History of Changes
Other Study ID Numbers: 010-02
Study First Received: March 29, 2007
Last Updated: October 18, 2007

Additional relevant MeSH terms:
Crohn Disease
Inflammatory Bowel Diseases
Gastrointestinal Diseases
Digestive System Diseases
Intestinal Diseases
Atorvastatin Calcium
Anticholesteremic Agents
Hypolipidemic Agents
Molecular Mechanisms of Pharmacological Action
Lipid Regulating Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Enzyme Inhibitors processed this record on September 19, 2017