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Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00424957
First Posted: January 22, 2007
Last Update Posted: February 5, 2009
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of Aarhus
  Purpose
The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.

Condition
Cirrhosis Hepatic Encephalopathy

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Brain Energy Metabolism in Patients With Acute Hepatic Encephalopathy Measured With PET

Resource links provided by NLM:


Further study details as provided by University of Aarhus:

Estimated Enrollment: 18
Study Start Date: November 2006
Study Completion Date: October 2008
Primary Completion Date: April 2007 (Final data collection date for primary outcome measure)
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   45 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy, 6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy, 6 healthy subjects age and sex matched
Criteria

Inclusion Criteria:

  • 6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy,
  • 6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy,
  • 6 healthy subjects age and sex matched

Exclusion Criteria:

  • Neurological and/or psychiatric condition,
  • Non-treated diabetes,
  • Pregnancy/breast-feeding
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00424957


Locations
Denmark
PET Centre, Aarhus University Hospital
Aarhus, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
Investigators
Study Chair: Susanne Keiding, MD PET Centre and Medical department V, Aarhus Sygehus, Aarhus University Hospital
  More Information

Additional Information:
Publications:
Responsible Party: Peter Iversen, PET Center, Aarhus University Hospital
ClinicalTrials.gov Identifier: NCT00424957     History of Changes
Other Study ID Numbers: 20060120
First Submitted: January 19, 2007
First Posted: January 22, 2007
Last Update Posted: February 5, 2009
Last Verified: February 2009

Keywords provided by University of Aarhus:
Ammonia
Astrocytes
Citric acid cycle
Alpha ketoglutarate dehydrogenase

Additional relevant MeSH terms:
Brain Diseases
Hepatic Encephalopathy
Central Nervous System Diseases
Nervous System Diseases
Liver Failure
Hepatic Insufficiency
Liver Diseases
Digestive System Diseases
Brain Diseases, Metabolic
Metabolic Diseases