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Relation Between Bone Density and the Regulation of Mineral Metabolism in Renal Stone Formers

This study has been completed.
Information provided by:
University Hospital Inselspital, Berne Identifier:
First received: December 26, 2006
Last updated: May 18, 2011
Last verified: May 2011
Accumulating evidence indicated that renal calcium stone formers often exhibit a low bone density. Therefore we want to test the hypothesis, that the mineral (calcium) metabolism is differently regulated in calcium stone formers with low as opposed to high bone density.

Calcium Nephrolithiasis

Study Type: Observational
Study Design: Observational Model: Case-Only
Official Title: Relation Between Bone Mineral Density and the Regulation of Mineral Metabolism in Renal Stone Formers

Resource links provided by NLM:

Further study details as provided by University Hospital Inselspital, Berne:

Estimated Enrollment: 90
Study Start Date: March 2004
Estimated Study Completion Date: June 2006
Detailed Description:

There is epidemiological evidence associating renal calcium stones and decreased bone mineral density (BMD). The decreased BMD in calcium stone formers is linked to hypercalciuria and both subtypes, fasting as well as absorptive hypercalciuria are associated with a diminished BMD. Higher 1,25-vitamin D plasma concentrations and lower PTH levels are encountered under free-choice diet conditions in patients diagnosed with absorptive and fasting hypercalciuria when compared to normocalciuric stone formers. Reports studying the BMD of stone formers and its link with mineral metabolism variables and urinary calcium excretion under different calcium intakes are rare.

We hypothesize now that PTH and 1,25-vitamin D change differently when calcium stone formers with high, intermediate and low BMD are challenged by a low calcium diet.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Recurrent renal calcium stone formers

Inclusion Criteria:

  • passage of at least one calcium containing kidney stone

Exclusion Criteria:

  • established cause of calcium stone formation (sarcoidosis, primary hyperparathyroidism etc.)
  • creatinine clearance < 60 ml/min
  • urinary tract infection
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Please refer to this study by its identifier: NCT00416052

Dept. Nephrology & Hypertension, Univ. Hospital Bern
Bern, Switzerland, 3010
Sponsors and Collaborators
University Hospital Inselspital, Berne
Study Director: Felix J Frey, MD University of Bern
  More Information

Responsible Party: Andreas Pasch, Department of Nephrology and Hypertension, Inselspital, University Hospital Bern Identifier: NCT00416052     History of Changes
Other Study ID Numbers: BE001
Study First Received: December 26, 2006
Last Updated: May 18, 2011

Keywords provided by University Hospital Inselspital, Berne:
1,25-vitamin D
bone mineral density

Additional relevant MeSH terms:
Kidney Calculi
Kidney Diseases
Urologic Diseases
Urinary Calculi
Pathological Conditions, Anatomical processed this record on September 21, 2017