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Investigation of Genetic Risk of Atrial Fibrillation

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ClinicalTrials.gov Identifier: NCT00412438
Recruitment Status : Unknown
Verified December 2006 by Nagoya University.
Recruitment status was:  Recruiting
First Posted : December 18, 2006
Last Update Posted : December 18, 2006
Sponsor:
Information provided by:
Nagoya University

Study Description
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Brief Summary:
The atrial fibrillation (AF) is the most common cardiac rhythm disturbance that is responsible for substantial morbidity and mortality independent of associated heart disease or other risk factors. Even in the absence of preexisting cardiovascular disease, AF remains significantly associated with excess mortality rates. The current unsatisfactory treatment for AF comes from lack of understanding of the pathophysiology of AF. The purpose of this study is to identify gene polymorphisms that confer susceptibility to atrial fibrillation. Patients with AF（N=500） and healthy volunteer（N=1000） without AF are enrolled in this study. Patients with coronary artery disease, severe valvular heart disease, cardiomyopathy or heart failure were excluded from the study.

Condition or disease
Atrial Fibrillation

Study Design
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Study Type : Observational
Enrollment : 1000 participants
Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Retrospective
Official Title: Investigation of Genetic Risk of Atrial Fibrillation
Study Start Date : October 2006

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Groups and Cohorts
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Outcome Measures
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Eligibility Criteria
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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Clinical diagnosis of atrial fibirillation

Exclusion Criteria:

  • coronary artery disease
  • severe valvular heart disease
  • cardiomyopathy
  • heart failure
Contacts and Locations
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00412438


Contacts
Contact: Kenji Yasui, MD, PhD +81-52-788-6211 kenji@riem.nagoya-u.ac.jp
Contact: Masaki Yamauchi, MD +81-52-788-6210 g030744d@mbox.nagoya-u.ac.jp

Locations
Japan
Department of Bio-information Analysis, Research Institute of Enviromental Medicine, Nagoya University Recruiting
Nagoya, Aichi, Japan
Contact: Kenji Yasui, MD, PhD    +81-52-6211    kenji@riem.nagoya-u.ac.jp   
Contact: Masaki Yamauchi, MD    +81-52-6211    g030744d@mbox.nagoya-u.ac.jp   
Sponsors and Collaborators
Nagoya University
Investigators
Study Chair: Kenji Yasui, MD, Phd Department of Bio-information Analysis, Research Institute of Enviromental Medicine, Nagoya University
More Information
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

ClinicalTrials.gov Identifier: NCT00412438     History of Changes
Other Study ID Numbers: RIEM-G-1
First Posted: December 18, 2006    Key Record Dates
Last Update Posted: December 18, 2006
Last Verified: December 2006

Keywords provided by Nagoya University:
Atrial Fibrillation

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes