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A Pilot Study of Tumor Cell Vaccine for High-risk Solid Tumor Patients Following Stem Cell Transplantation

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ClinicalTrials.gov Identifier: NCT00405327
Recruitment Status : Completed
First Posted : November 30, 2006
Last Update Posted : November 6, 2017
Sponsor:
Information provided by (Responsible Party):
James Geiger, MD, University of Michigan Cancer Center

Brief Summary:

Localized solid tumors such as, sarcoma, neuroblastoma, and Wilms' tumor, can generally be effectively treated with a combination of surgery, radiation and chemotherapy. However, patients with metastatic or relapsed disease have a very poor prognosis.

New approaches to the management of these difficult groups of patients are needed. There is evidence to suggest that solid tumors may be good candidates for immunotherapy approaches. In fact, recent experimental evidence indicates that the period of lymphopenia that occurs after stem cell transplant may be an opportune time to use an immunotherapy treatment approach. In light of the very poor prognosis of young patients with advanced solid tumors, this treatment approach warrants further investigation.


Condition or disease Intervention/treatment Phase
Sarcoma Neuroblastoma Wilm's Tumor Biological: Tumor lysate-pulsed dendritic cell (DC) vaccine Other: Hematopoietic stem cell transplantation (HSCT) Phase 2

Detailed Description:

Localized solid tumors such as, sarcoma, neuroblastoma, and Wilms' tumor, can generally be effectively treated with a combination of surgery, radiation and chemotherapy. However, patients with metastatic or relapsed disease have a very poor prognosis.

For the past decade, efforts to increase overall survival and progression-free survival for patients with high-risk pediatric and young adult tumors, have evaluated the use of high-dose chemotherapy and hematopoietic stem cell transplantation (HSCT). The proportion of patients who enter a complete remission with HSCT is high, ranging from 81 to 90%. While autologous HSCT renders a large proportion of patients temporarily disease-free, relapse develops in the majority of patients.

Survival appears to have been most improved with this strategy for neuroblastoma, but relapses occur in the majority of patients. Similar strategies have also been tried for patients with advanced stage sarcoma and Wilms' tumor, but relapses are even more problematic.

New approaches to the management of these difficult groups of patients are needed. There is evidence to suggest that solid tumors may be good candidates for immunotherapy approaches. In fact, recent experimental evidence indicates that the period of lymphopenia that occurs after HSCT may be an opportune time to use this treatment approach. In light of the very poor prognosis of young patients with advanced solid tumors, this treatment approach warrants further investigation.


Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 16 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Pilot Study of Tumor Lysate-pulsed Dendritic Cell Vaccine for Immune Augmentation for High-risk Solid Tumor Patients Following Autologous Stem Cell Transplantation
Study Start Date : June 2006
Actual Primary Completion Date : June 2009
Actual Study Completion Date : June 2010


Arm Intervention/treatment
Experimental: DC vaccine therapy
Tumor lysate-pulsed dendritic cell (DC) vaccine following HSCT
Biological: Tumor lysate-pulsed dendritic cell (DC) vaccine
Tumor lysate-pulsed dendritic cell vaccine

Other: Hematopoietic stem cell transplantation (HSCT)
Hematopoietic stem cell transplantation (HSCT)




Primary Outcome Measures :
  1. To estimate the rate of immune response of this immunotherapy treatment [ Time Frame: 70 days ]

Secondary Outcome Measures :
  1. To correlate and characterize the immune response to the clinical response. [ Time Frame: three years ]
  2. To define immunologic endpoints that can serve as surrogates of clinical response. [ Time Frame: three years ]


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Ages Eligible for Study:   up to 30 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Eligibility

Inclusion Criteria:

To participate in this study, it is necessary to collect sufficient tumor and peripheral blood stem cells to both develop the vaccine and perform the autologous stem cell transplant. Patients who also have previously had tumor or stem cells collected, which are available and sufficient for this study, are eligible to participate as study subjects.

  1. Patients must have a histologically verified diagnosis of neuroblastoma, Wilm's tumor, or sarcoma, including rhabdomyosarcoma, a Ewing's sarcoma family tumor (ES, PNET), synovial sarcoma, fibrosarcoma, or desmoplastic round cell tumor.

    and must meet one of the following criteria:

    1. have metastatic disease at diagnosis
    2. have never achieved complete remission following frontline standard therapy
    3. have relapsed after receiving standard therapy
  2. Patients must have been < 30 years of age at the time of original diagnosis.
  3. Patients must have a source of tumor tissue from which approximately 1 gram of viable tumor can be obtained for vaccine development.
  4. Patients must have a good performance status (>70% by Lansky or Karnofsky scales).
  5. Patients must have a life expectancy of at least 16 weeks.
  6. Females of child-bearing age (>= 12 years old) must have a negative pregnancy test.

    Patients may enroll on this study at various points in their treatment including diagnosis, recurrence, or just prior to initiation of study mandated transplant therapy. Because patients may enter this study prior to completion of retransplant treatments, the below criteria must be met only to proceed to the high dose chemotherapy and autologous stem cell transplant part of this study. These criteria are not a requirement to enter this study in order to collect tumor or peripheral blood stem cells.

  7. Patients must have achieved complete response or very good partial response(>= 90% decrease in tumor volume) before proceeding to transplant. For patients enrolling on this study just prior to transplant a VGPR or CR must be achieved to be eligible.
  8. Patients may have undergone prior autologous peripheral blood stem cell transplantation, provided at least 12 months have elapsed prior to entry on this study.
  9. Patients must have had a successful peripheral blood stem cell collection, with cryopreservation of PBSCs for both engraftment and for generation of dendritic cells.
  10. Adequate baseline organ function must be present:

    hematologic parameters (not applicable if bone marrow is involved with tumor):

    1. ANC > 500/mm3
    2. platelet count > 50,000/mm3
    3. serum creatinine < 1.5x upper limit of normal for age
    4. serum hepatic transaminases (AST, ALT) < 3x upper limit of normal
    5. serum bilirubin < 1.5x upper limit of normal
    6. cardiac echocardiogram with either SF > 27% or EF > 50%. A comparable EF on a MUGA scan will also meet eligibility criteria.
  11. Give or obtain informed consent

Exclusion Criteria:

  1. Patients who have received prior antitumor vaccines are ineligible
  2. Patients who meet the response criteria but progress prior to study enrollment are ineligible
  3. Patients with known autoimmune diseases or conditions are ineligible
  4. Patients with HIV infection, AIDS, hepatitis B surface antigen positivity, ongoing bleeding, or any significant uncontrolled medical or psychiatric illness are ineligible.
  5. Patients under treatment for infection must cleared by BMT physician prior to enrollment.
  6. Patients who are pregnant or nursing are ineligible
  7. Prior allogenic transplant

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00405327


Locations
United States, Michigan
University of Michigan, Department of Surgery, Pediatric Section
Ann Arbor, Michigan, United States, 48170
Sponsors and Collaborators
University of Michigan Cancer Center
Investigators
Principal Investigator: James D Geiger, M.D. University of Michigan, Department of Surgery, Pediatric Section

Responsible Party: James Geiger, MD, Professor of Surgery, Pediatric Surgery Section, University of Michigan Cancer Center
ClinicalTrials.gov Identifier: NCT00405327     History of Changes
Other Study ID Numbers: UMCC 2005.050
GCRC ID # 2191
HUM00002650 ( Other Identifier: University of Michigan Medical School )
First Posted: November 30, 2006    Key Record Dates
Last Update Posted: November 6, 2017
Last Verified: November 2017

Keywords provided by James Geiger, MD, University of Michigan Cancer Center:
tumor vaccine
metastatic solid tumors
recurrent tumors

Additional relevant MeSH terms:
Neuroblastoma
Wilms Tumor
Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumors, Primitive
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Neoplasms, Complex and Mixed
Kidney Neoplasms
Urologic Neoplasms
Urogenital Neoplasms
Neoplasms by Site
Neoplastic Syndromes, Hereditary
Kidney Diseases
Urologic Diseases
Genetic Diseases, Inborn
Vaccines
Immunologic Factors
Physiological Effects of Drugs