Study of PEG-Intron for Plexiform Neurofibromas
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|ClinicalTrials.gov Identifier: NCT00396019|
Recruitment Status : Completed
First Posted : November 6, 2006
Results First Posted : November 6, 2017
Last Update Posted : November 6, 2017
This study is for slow growing tumors called plexiform neurofibromas (PNF) which are a relatively common problem in people with neurofibromatosis type 1 (NF1). These tumors are benign but as they grow, they can become disfiguring as well as disabling or even life threatening. They often cause pain, difficulty using arms or legs because of spinal cord compression, and/or nerve damage. At present, the only available therapy for plexiform neurofibromas is to try to surgically remove as much of the tumor as is possible. Because these tumors grow into the surrounding areas, total surgical resection is often impossible. Most tumors will re-grow after surgery if the entire tumor cannot be removed. To date, other treatments including chemotherapy and radiotherapy have not been able to shrink these tumors.
Interferon is a drug that is used for different types of tumors as well as for hepatitis. It has been used in the treatment of plexiform neurofibromas (PNF) with some subjects showing improvement in symptoms and/or a decrease in the size of the tumor. Most subjects had no further growth of their tumor while on the PEG-Intron. The drug used in this study is PEG (pegylated)-Intron. PEG-Intron is a long acting form of interferon which keeps the drug from being broken down in the body for a longer period of time and potentially could be more effective than the short-acting interferon. PEG-Intron has been approved by the Food and Drug Administration (FDA) for the treatment of Hepatitis C.
The goals of this study are:
- To determine how your child's plexiform neurofibroma responds to PEG-Intron when given weekly.
- To determine the side effects of PEG-Intron when given weekly to participants with plexiform neurofibromas.
- To evaluate a new method of measuring changes in the size of tumors called volume analysis. This method measures the entire volume of a tumor in three dimensions. The standard method of measuring tumors uses only the length and/or width of the tumor. By studying the different ways of measuring tumors the investigators hope to be able to determine which method is the most accurate and useful.
|Condition or disease||Intervention/treatment||Phase|
|Plexiform Neurofibroma||Drug: PEG-Intron||Phase 2|
PEG-Intron will be given every week through a small needle under the skin, in the same way that insulin is given to people with diabetes. Subjects will be taught to do this at home. As long as the tumor isn't growing and the side effects are tolerable, the injections will be given once a week for 2 years.
Children will be enrolled on the study into one of three strata (patient groups): strata 1 includes children who do not have any symptoms associated with their PNF and MRI scans over the past year may or may not show tumor growth, strata 2 includes children who have symptoms associated with the PNF but MRI scans over the past year have not shown growth and strata 3 includes children who have shown an increase in the size of the PNF on MRI scans over the past year, with or without any symptoms.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||86 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||A Phase II Trial of Peginterferon Alfa-2b (PEG-Intron) for Plexiform Neurofibromas|
|Actual Study Start Date :||December 2006|
|Actual Primary Completion Date :||April 2014|
|Actual Study Completion Date :||April 2014|
- Number of Participants With Imaging Response in Strata 1 and 2 [ Time Frame: MRI scans were performed at baseline and at months 4, 8, 12, 18, and 24 while on treatment and every 6 months thereafter until off study. ]A response was defined as a ≥20% reduction in the sum of the volume of the "target" plexiform neurofibroma ( PN) within 12 months confirmed by a follow-up MRI after ≥4 weeks.
- Clinical Response in Stratum 2 [ Time Frame: baseline, week 6, months 4, 8, 12, 18, and 24 while on treatment and every 6 months thereafter until off study ]Clinical response was defined as a protocol-specified improvement in ophthalmologic evaluation, an improvement of at least one level in performance status (PS) ≥50% decrease in the amount of pain medications required per week compared with baseline or ability to change from a narcotic to a nonnarcotic analgesic, sustained for at least one month.
- Time to Progression (TTP) in Stratum 3 [ Time Frame: baseline, week 6, months 4, 8, 12, 18, and 24 while on treatment and every 6 months thereafter until off study ]TTP was estimated by the Kaplan-Meter method
- Number of Participants With Imaging Response in Stratum 3 [ Time Frame: MRI scans were performed at baseline and at months 4, 8, 12, 18, and 24 while on treatment and every 6 months thereafter until off study ]A Response was defined as a ≥ 20% reduction in the sum of the volume of the "target" plexiform neurofibroma (PN) within 12 months, confirmed by a follow-up MRI after ≥ 24 weeks
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00396019
|United States, Pennsylvania|
|Children's Hospital of Pittsburgh of UPMC|
|Pittsburgh, Pennsylvania, United States, 15224|
|Principal Investigator:||Jean Tersak, M.D.||University of Pittsburgh|