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The Combined Effect of 2,3-Dimercaptosuccinic Acid and Multi-Nutrients on Children in Lead Poisoning

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00374894
First Posted: September 12, 2006
Last Update Posted: September 12, 2006
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
China Medical University, China
  Purpose
Lead poisoning remains a common disease among children despite successful public health efforts that reduced its prevalence.Our study was designed to test the hypothesis that lead-poisoning children (BLLs:100-440µg/L) who were given DMSA and multi-nutrients would have a greater fall than children of other groups at 12 weeks of follow-up.

Condition Intervention
Lead Poisoning Drug: 2,3-dimercaptosuccinic acid

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by China Medical University, China:

Estimated Enrollment: 500
Study Start Date: March 2004
Estimated Study Completion Date: August 2004
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   3 Years to 6 Years   (Child)
Sexes Eligible for Study:   All
Criteria

Inclusion Criteria:

  • Initial BLLs 100-440µg/L
  • Age 3-6y
  • No more than two main residences
  • House cleaned (no lead contaminated)
  • Normal intake history and physical

Exclusion Criteria:

  • Chelation in the past 12 weeks
  • Concomitant Fe deficiency(ferritin<16ng/ml)
  • Hemoglobin<10.5g/dL
  • Medications affecting mineral metabolism
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00374894


Locations
China, Liaoning
China Medical University
Shenyang, Liaoning, China, 110001
Sponsors and Collaborators
China Medical University, China
Investigators
Study Director: Jin Ya ping, professor Department of Environmental and Occupational Health
  More Information

Publications:
CDC.Preventing lead poisoning in young children[R]. U.D.Dept of health and Human services 1991:1.

ClinicalTrials.gov Identifier: NCT00374894     History of Changes
Other Study ID Numbers: 20032063 - 2001102049
First Submitted: September 11, 2006
First Posted: September 12, 2006
Last Update Posted: September 12, 2006
Last Verified: April 2004

Keywords provided by China Medical University, China:
2,3-dimercaptosuccinic acid
Blood Lead Levels
children
multi-nutrients

Additional relevant MeSH terms:
Poisoning
Lead Poisoning
Chemically-Induced Disorders
Succimer
Antidotes
Protective Agents
Physiological Effects of Drugs
Chelating Agents
Sequestering Agents
Molecular Mechanisms of Pharmacological Action


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