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Atrial Fibrillation and the Risk for Neurological Complications

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ClinicalTrials.gov Identifier: NCT00357227
Recruitment Status : Unknown
Verified April 2007 by University Hospital Muenster.
Recruitment status was:  Recruiting
First Posted : July 27, 2006
Last Update Posted : April 19, 2007
Sponsor:
Collaborator:
German Federal Ministry of Education and Research
Information provided by:
University Hospital Muenster

Study Description
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Brief Summary:

B8: Atrial fibrillation and the risk of neurological complications

Twenty-five thousand acute strokes are caused by atrial fibrillation every year. But even more frequent than symptomatic strokes are silent infarctions of the brain. Silent strokes remain undetected in most cases, but cumulate over time and progressively impair cognition. The impact of atrial fibrillation on subacute brain infarctions is not yet known. Moreover, it has not been elucidated so far how effective different therapeutic strategies in the treatment of atrial fibrillation prevent cognitive impairment. Thus, this study aims at evaluating the influence of different types of atrial fibrillation on silent strokes and the related impairment in cognitive functions. Other risk factors and cardiovascular diseases that are known to provoke the development of strokes will be assessed as well. So, it will be possible to isolate the contribution of atrial fibrillation to silent strokes and related cognitive impairment in segregation to other relevant factors. AF patients and controls will be examined twice in two years in order to evaluate the role of atrial fibrillation and differential therapeutic interventions with regard to the progression of silent strokes and cognitive impairment in a within subject-design.


Condition or disease
Atrial Fibrillation

Study Design
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Study Type : Observational
Enrollment : 1000 participants
Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Atrial Fibrillation and the Risk for Neurological Complications
Study Start Date : January 2004

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Groups and Cohorts
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Outcome Measures
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Eligibility Criteria
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Ages Eligible for Study:   50 Years to 85 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Clinical diagnosis of permanent, paroxysmal or episodic atrial fibrillation in the past or at present

Exclusion Criteria:

  • Pacemaker
  • Metal implants
  • History of acute stroke
  • Diagnosis of vascular or degenerative dementia
  • History of brain tumors
  • History of severe brain injury
  • History of psychiatric disorders
  • Pregnancy
Contacts and Locations
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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00357227


Contacts
Contact: Stefan Knecht, Prof. +49-251-83- ext 48195 knecht@uni-muenster.de

Locations
Germany
University Hospital Münster, Dept. of Neurology Recruiting
Münster, NRW, Germany, 48149
Principal Investigator: Stefan Knecht, Prof.         
Sponsors and Collaborators
University Hospital Muenster
German Federal Ministry of Education and Research
Investigators
Principal Investigator: Stefan Knecht, Prof. University Hospital Münster, Department of Neurology
More Information
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Additional Information:
University Hospital Muenster, Dept. of Neurology  This link exits the ClinicalTrials.gov site

ClinicalTrials.gov Identifier: NCT00357227     History of Changes
Other Study ID Numbers: 01 GI 0204
First Posted: July 27, 2006    Key Record Dates
Last Update Posted: April 19, 2007
Last Verified: April 2007

Keywords provided by University Hospital Muenster:
Atrial fibrillation
Stroke
Vascular Dementia
Mild Cognitive Impairment

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Heart Diseases
Cardiovascular Diseases
Pathologic Processes