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Atrial Fibrillation and the Risk for Neurological Complications
Recruitment status was: Recruiting
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Purpose
B8: Atrial fibrillation and the risk of neurological complications
Twenty-five thousand acute strokes are caused by atrial fibrillation every year. But even more frequent than symptomatic strokes are silent infarctions of the brain. Silent strokes remain undetected in most cases, but cumulate over time and progressively impair cognition. The impact of atrial fibrillation on subacute brain infarctions is not yet known. Moreover, it has not been elucidated so far how effective different therapeutic strategies in the treatment of atrial fibrillation prevent cognitive impairment. Thus, this study aims at evaluating the influence of different types of atrial fibrillation on silent strokes and the related impairment in cognitive functions. Other risk factors and cardiovascular diseases that are known to provoke the development of strokes will be assessed as well. So, it will be possible to isolate the contribution of atrial fibrillation to silent strokes and related cognitive impairment in segregation to other relevant factors. AF patients and controls will be examined twice in two years in order to evaluate the role of atrial fibrillation and differential therapeutic interventions with regard to the progression of silent strokes and cognitive impairment in a within subject-design.
| Study Type: | Observational |
| Study Design: | Observational Model: Defined Population Observational Model: Natural History Time Perspective: Longitudinal Time Perspective: Prospective |
| Official Title: | Atrial Fibrillation and the Risk for Neurological Complications |
Eligibility| Ages Eligible for Study: | 50 Years to 85 Years (Adult, Senior) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Clinical diagnosis of permanent, paroxysmal or episodic atrial fibrillation in the past or at present
Exclusion Criteria:
- Pacemaker
- Metal implants
- History of acute stroke
- Diagnosis of vascular or degenerative dementia
- History of brain tumors
- History of severe brain injury
- History of psychiatric disorders
- Pregnancy
Contacts and LocationsPlease refer to this study by its ClinicalTrials.gov identifier: NCT00357227
| Contact: Stefan Knecht, Prof. | +49-251-83- ext 48195 | knecht@uni-muenster.de |
| Germany | |
| University Hospital Münster, Dept. of Neurology | Recruiting |
| Münster, NRW, Germany, 48149 | |
| Principal Investigator: Stefan Knecht, Prof. | |
| Principal Investigator: | Stefan Knecht, Prof. | University Hospital Münster, Department of Neurology |
More Information
Additional Information:
| ClinicalTrials.gov Identifier: | NCT00357227 History of Changes |
| Other Study ID Numbers: |
01 GI 0204 |
| Study First Received: | July 25, 2006 |
| Last Updated: | April 18, 2007 |
Keywords provided by University Hospital Muenster:
|
Atrial fibrillation Stroke Vascular Dementia Mild Cognitive Impairment |
Additional relevant MeSH terms:
|
Atrial Fibrillation Arrhythmias, Cardiac Heart Diseases Cardiovascular Diseases Pathologic Processes |
ClinicalTrials.gov processed this record on June 23, 2017