Association Between Hepatitis C Virus Infection and Hematologic and Thyroid Cancers
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ClinicalTrials.gov Identifier: NCT00342641 |
Recruitment Status
:
Completed
First Posted
: June 21, 2006
Last Update Posted
: July 2, 2017
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This study will investigate the possible relationship between infection with hepatitis C virus (HCV) and the development of certain hematologic cancers (Non-Hodgkin's lymphoma, Hodgkin's lymphoma, chronic lymphocytic leukemia, multiple myeloma) and thyroid cancer. HCV causes chronic hepatitis, cirrhosis, and liver cancer. It is transmitted primarily through injection drug use and transfusion of infected blood. Studies have shown that HCV may also be linked to hematologic cancers and thyroid cancer.
This retrospective study will examine medical records from veterans with and without HCV infection who previously received treatment in the Veterans Administration medical system. Data collected on each subject will include the subject's race, sex, age and era of military service, presence of liver disease or thyroiditis at their baseline clinic visit, number of inpatient visits in the past 5 years and outpatient visits in the past year, and the presence of various specified cancers. The prevalence of cancer and other conditions among HCV-infected subjects and non-HCV infected subjects at baseline and the subsequent development of the cancers of interest in these two groups will be compared and analyzed for a possible causal relationship.
Condition or disease |
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Hepatitis C Virus |
Hepatitis C virus (HCV) may be a cause of hematologic malignancies and thyroid cancer. HCV infection is common among U.S. military veterans receiving care in the Veterans Administration healthcare system. The investigators propose a retrospective cohort study using VA administrative databases. A cohort of approximately 147,000 HCV-infected veterans has been identified for the period 1997-2004. Likewise, a cohort of approximately 573,000 HCV-uninfected veterans has been identified for the same period. These subjects are being evaluated for the diagnosis of hematologic malignancies, thyroid cancer, and related medical conditions as recorded in VA databases. The comparison of the prevalence and incidence of these cancers in the two cohorts will provide a test of the hypothesis that HCV infection can cause these cancers.
The investigators will also evaluate the association between HCV infection and several other medical conditions, which might be related to HCV infection, specifically: immune thrombocytopenic purpura, autoimmune hemolytic anemia, cholangiocarcinoma, cholangitis, and pancreatic cancer.
Study Type : | Observational |
Estimated Enrollment : | 815000 participants |
Official Title: | Associations of Hematologic Malignancies and Thyroid Cancer With HCV Infection Among US Military Veterans |
Study Start Date : | June 8, 2005 |
Study Completion Date : | December 13, 2011 |

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Ages Eligible for Study: | Child, Adult, Senior |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
- None given.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00342641
United States, Texas | |
Houston Veterans AFfairs Medical Center | |
Houston, Texas, United States |
Publications:
ClinicalTrials.gov Identifier: | NCT00342641 History of Changes |
Other Study ID Numbers: |
999905172 05-C-N172 |
First Posted: | June 21, 2006 Key Record Dates |
Last Update Posted: | July 2, 2017 |
Last Verified: | December 13, 2011 |
Keywords provided by National Institutes of Health Clinical Center (CC):
Lymphoma Multiple Myeloma Thyroiditis |
Cohort Study Record linkage study Hepatitis C |
Additional relevant MeSH terms:
Hepatitis Hepatitis A Hepatitis C Thyroid Neoplasms Liver Diseases Digestive System Diseases Hepatitis, Viral, Human Virus Diseases Enterovirus Infections |
Picornaviridae Infections RNA Virus Infections Flaviviridae Infections Endocrine Gland Neoplasms Neoplasms by Site Neoplasms Head and Neck Neoplasms Endocrine System Diseases Thyroid Diseases |