Computer-Based Training for Cognitive Enhancement: In Home Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00337974
Recruitment Status : Completed
First Posted : June 20, 2006
Last Update Posted : November 2, 2015
Information provided by (Responsible Party):
Posit Science Corporation

Brief Summary:
The primary objective of this study is to evaluate the effects of a computer-based training program on the memory and cognitive abilities of mature individuals undergoing healthy aging.

Condition or disease Intervention/treatment Phase
Aging Other: Computerized Plasticity-Based Adaptive Cognitive Training Other: Educational DVDs Not Applicable

Detailed Description:

The computer-based training program is focused on speech reception to strengthen an individual's memory for speech. This type of training program was chosen because speech perception and memory are crucial elements of human communication and losses in this area are often the first signal of overall cognitive decline.

Subjects meeting eligibility criteria and providing written, informed consent are randomized to three groups; two 40-session, computerized training programs or a no contact control group.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 182 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Computer-Based Training for Cognitive Enhancement: In Home Study
Study Start Date : March 2005
Actual Primary Completion Date : January 2006
Actual Study Completion Date : January 2006

Arm Intervention/treatment
Experimental: Experimental Treatment
Computerized Plasticity-Based Adaptive Cognitive Training
Other: Computerized Plasticity-Based Adaptive Cognitive Training
Other Names:
  • BrainHQ
  • Brain Fitness Program

Active Comparator: Active Control
Educational DVDs
Other: Educational DVDs
No Intervention: No Contact Control

Primary Outcome Measures :
  1. Evaluation of training effects.

Secondary Outcome Measures :
  1. Safety effects of computer-based training.

Information from the National Library of Medicine

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Ages Eligible for Study:   60 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

A)Participants must be at least 60 years old B)Participants must have a Mini-Mental State Exam (MMSE) score of 24 or higher to ensure that participants do not meet common criteria for dementia C)Participants must be a native English speaker D)Participants must be able to see well enough to read the consent form E)Participants must be able to hear well enough to understand ordinary spoken conversation in a slightly noisy room F)Participants must be willing to commit to the time requirements of the study and not have any scheduled trips or absences for more than 1 week during the training.

Exclusion Criteria A)Participants must not be planning to begin cholinesterase inhibitor (AChEI) therapy or to change their dosing levels. Subjects currently using AChEI will be included if they have an established steady dosing history at least one month prior to the study and are expected to continue at the same dosage throughout the study.

B)Participants must not have had a head trauma that caused them to lose consciousness.

C)Participants must not have had a stroke within the past year; or have had a stroke that has left them with expressive or receptive language problems.

D)Participants must not have any central nervous system disorder that could contribute to cognitive impairment.

E)Participants must not have a tremor preventing the use of a computer mouse or other pointing device.

F)Participants must not currently be active in another clinical trial.

Exclusion Criteria:

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00337974

United States, California
Posit Science Corporation
San Francisco, California, United States, 94108
Sponsors and Collaborators
Posit Science Corporation
Principal Investigator: Henry W Mahncke, PhD Posit Science Corporation

Publications of Results:
Responsible Party: Posit Science Corporation Identifier: NCT00337974     History of Changes
Other Study ID Numbers: OUT-106-2005
First Posted: June 20, 2006    Key Record Dates
Last Update Posted: November 2, 2015
Last Verified: October 2015

Keywords provided by Posit Science Corporation:
cognitive enhancement
auditory memory