Zambia Exclusive Breastfeeding Study
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|ClinicalTrials.gov Identifier: NCT00310726|
Recruitment Status : Completed
First Posted : April 4, 2006
Last Update Posted : July 27, 2011
|Condition or disease||Intervention/treatment||Phase|
|HIV Infection||Other: abrupt weaning at 4 months Other: Continued exclusive breastfeeding||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||1435 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Short Duration Exclusive Breastfeeding With Abrupt Weaning to Reduce the Risk of Mother-to-Child HIV Transmission|
|Study Start Date :||May 2001|
|Actual Primary Completion Date :||December 2006|
|Actual Study Completion Date :||December 2006|
Experimental: Abrupt Weaning
Women were counseled to abruptly wean their child at 4 months of age.
Other: abrupt weaning at 4 months
abrupt weaning at 4 months
Active Comparator: Exclusive breastfeeding per WHO guidelines
Women were counseled to adhere to the WHO recommendations for duration of exclusive breastfeeding.
Other: Continued exclusive breastfeeding
Continued exclusive breastfeeding
- HIV infection detected by 4 months among children with no evidence of HIV infection at birth. [ Time Frame: 24 months of age ]
- Magnitude of the reduction in mother-to-child HIV transmission and the magnitude of the increase in non-HIV-related under-2-year mortality, attributable to cessation of breastfeeding at 4 months.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00310726
|George and Chawama District Health Clinics|
|Principal Investigator:||Louise Kuhn, PhD||Gertrude H. Sergievsky Center, and Department of Epidemiology, Mailman School of Public Health, Columbia University|
|Principal Investigator:||Donald M Thea, MD, MSc||Department of International Health, Boston University School of Public Health|