Smoking While on Transdermal Nicotine Replacement Therapy: Effects on Craving and Cessation
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Smoking while on nicotine patches will help subjects to reduce their expired carbon monoxide levels from the levels they were before they started using the patch. Subjects will also decrease their daily consumption of cigarettes, change how they smoke the cigarette, and will show reduced reactivity to smoking-related cues and reduced craving.
Condition or disease
Subjects who smoke while on an individually dosed tNRT will reduce their expired carbon monoxide levels from pre- to post-treatment conditions. They will also decrease their daily consumption of cigarettes, change their smoking topography, and will show reduced reactivity to smoking-related cues and reduced craving.
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Ages Eligible for Study:
19 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
at least 19 years of age
male or female
have intention to quit smoking within the next 6 months
smoke 10 or more cigarettes per day
Pregnant or not using an adequate enough method of birth control to ensure that they are not at risk of becoming pregnant
have any generalized skin disorders
are in an immediate post-myocardial infarction period or have life-threatening arrhythmias, have severe or worsening angina pectoris or have had a recent cerebral vascular accident
are using additional nicotine replacement therapies or any other smoking cessation pharmacotherapy
any clinically significant ECG abnormalities
any known hypersensitivity to components of the transdermal system