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Short-Term Androgen Priming Before COS Using Aromatase Inhibitor and hCG During Early-Follicular-Phase GnRH Antagonist Administration - a Randomized Controlled Trial

This study has been completed.
Information provided by:
Rigshospitalet, Denmark Identifier:
First received: February 1, 2006
Last updated: April 20, 2007
Last verified: April 2007
We want to investigate if early follicular phase downregulation and androgen priming, by use of GnRH antagonist, aromatase inhibitor and hCG before COH in a short protocol, shows signs of improvement compared to standard short antagonist protocol

Condition Intervention Phase
Drug: Downregulation and androgen priming by use of GnRH antagonist, aromatase inhibitor and hCG before COH
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment

Further study details as provided by Rigshospitalet, Denmark:


Ages Eligible for Study:   18 Years to 39 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Indication and wish for IVF/ICSI treatment
  • Womens age 20-39 years (both inclusive)
  • Regular menstrual cycle within normal range
  • Body Mass Index: 18-30 kg/m2 (both inclusive)
  • Negative pregnancy test before treatment
  • A maximum of 3 earlier IVF/ICSI treatments that did not result in pregnancy

Exclusion Criteria:

  • serious systemic disease
  • Presence of polycystic ovarian syndrome (PCOS)
  • Earlier poor response with less than 4 mature follicles
  • Earlier participation in the investigation
  Contacts and Locations
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Please refer to this study by its identifier: NCT00286364

The Fertility Clinic 4071, Copenhagen University Hospital Rigshospitalet
Copenhagen, Copenhagen East, Denmark, 2100
Sponsors and Collaborators
Rigshospitalet, Denmark
Principal Investigator: Kristine Lossl, medical doctor The Fertility Clinic 4071, Copenhagen University Hospital Rigshospitalet
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00286364     History of Changes
Obsolete Identifiers: NCT00150501
Other Study ID Numbers: version 01.2005-05-20
Study First Received: February 1, 2006
Last Updated: April 20, 2007

Additional relevant MeSH terms:
Genital Diseases, Male
Genital Diseases, Female
Aromatase Inhibitors
Steroid Synthesis Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Estrogen Antagonists
Hormone Antagonists
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Hormones processed this record on May 25, 2017