Treatment Effects From Aerobic Endurance Training and Maximal Strength Training in Patients Suffering From Schizophrenia
|ClinicalTrials.gov Identifier: NCT00286299|
Recruitment Status : Completed
First Posted : February 3, 2006
Last Update Posted : March 29, 2017
|Condition or disease||Intervention/treatment||Phase|
|Schizophrenia Cardiovascular Disease||Other: Aerobic high-intensity interval training (AIT) Other: Computer game training (CG) Other: Maximal strength training||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||33 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Physiological and Psychiatric Effects From Aerobic High Intensity Endurance Training and Maximal Strength Training in Patients Suffering From Schizophrenia: A Controlled Clinical Trial.|
|Actual Study Start Date :||October 2005|
|Actual Primary Completion Date :||July 2008|
|Actual Study Completion Date :||July 2008|
Experimental: Aerobic interval training (AIT)
AIT is 4x4 minutes interval training on a treadmill at 85 to 95 % HRpeak interspersed with 3 min of active resting periods at a work load corresponding to 70 % HRpeak between each interval. Patients performed the intervals walking or running with a minimum of 5 % inclination.
Other: Aerobic high-intensity interval training (AIT)
The AIT group trains 4x4 minute interval training on a treadmill at 85-95 % HRpeak interspersed with 3 minutes of active resting periods at a work load corresponding to 70% HRpeak between each interval. All training sessions are monitored and start with a 6 minute warm-up and end with a 5 minute cool-down period at a work load corresponding to 70% HRpeak. Intervals are performed walking or running on a treadmill with a minimum of 5% inclination, 3 times per week for 8 weeks.
Other Name: 4x4 interval
Active Comparator: Computer game training (CG)
36 minutes playing supervised computer games, Tetris, Xbox
Other: Computer game training (CG)
The CG spend the same amount of time (36 minutes), training to improve their ability in the computer game, Tetris. Tetris is a game where small shapes called Tetraminoes fall from the top of the Playfield to the bottom. Players must rotate the Tetraminoes as they fall and fit them together to complete lines. When the player fills an entire line with blocks, that line is removed from the screen. If the player cannot complete lines, the blocks will eventually rise past the top of the screen, and the game ends.
Other Name: Tetris THQ Inc., Xbox, Microsoft
Experimental: Maximal strength training (MST)
MST is performed in a leg press machine. The weight is lowered in a controlled manner in the eccentric phase until the patient reached 90 degrees in the knee joint. Then the patients has a short stop (~0.5 second) before the weight is moved as rapidly as possible to complete extension. The training volume is 4 sets of 4RM (i.e. 85-90 % 1RM). The training load is increased with 2.5-5 kg each time patients managed to perform 4 sets with the determined load or each training session.
Other: Maximal strength training
Training starts with a 10 minute warm-up on the treadmill. Maximal strength training is then performed in an inclined leg press machine. The subject lifts 4 maximal repetitions that are repeated 4 times after a 2 minute rest period. Subjects are instructed to lift the weight with an intention of maximal mobilization of force. Training load is increased each time the subject manage to perform 4x4 maximal repetitions. Training is carried out 3 times per week in 8 weeks.
- peak aerobic capacity (VO2peak) [ Time Frame: Pre- and Posttest ]
- Positive and Negative Syndrome Scale (PANSS) [ Time Frame: Pre- and Posttest ]
- Calgary Depression Scale for Schizophrenia (CDSS) [ Time Frame: Pre- and Posttest ]
- The 36-item short form (SF-36) [ Time Frame: Pre- and Posttest ]
- 60 Watt walking efficiency, Net efficiency [ Time Frame: Pre- and Posttest ]
- Maximal strength, measured as one repetition maximum (1RM) in a incline leg press machine (Technogym) [ Time Frame: Pre- and Post test ]
- Fasting blood samples, systolic and diastolic blood pressure. [ Time Frame: Pre- and posttest ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00286299
|St. Olavs Hospital, Department of Psychiatry|
|Trondheim, Norway, 7041|
|Study Chair:||Geir Nilsberg, M.D.||Norwegian University og Science and Technology|
|Principal Investigator:||Jørn Heggelund, M.Sc.||Norwegian University of Science and Technology|