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The Effect of Obesity on Lung Functioning

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00284895
Recruitment Status : Completed
First Posted : February 1, 2006
Last Update Posted : March 29, 2017
Information provided by:
National Jewish Health

Brief Summary:

This research study is looking at the effects of weight loss, due to surgery or structured weight-loss program on lung function, inflammation in your body and lungs, asthma and asthma symptoms. This study is important because we will be better able to understand the effect of weight on lung functioning and asthma. Approximately 20 research subjects will be enrolling in this study at National Jewish.

Adults with asthma who has elected to undergo weight-reduction surgery may qualify for the participation. Involvement will last about 1 year.

Condition or disease
Obesity Asthma

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Study Type : Observational
Actual Enrollment : 40 participants
Time Perspective: Prospective
Official Title: The Effect of Medical and Surgical Weight Loss on Pulmonary Physiology and Airway
Study Start Date : November 2005
Actual Primary Completion Date : July 2007
Actual Study Completion Date : November 2007

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Weight Control

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Adults (≥18yr) who report a physician's diagnosis of asthma and have taken any asthma medication within the last 2 weeks.
  • Obesity (Body Mass Index (BMI) ≥40, or ≥35 with comorbidities, as per published guidelines for qualification for bariatric surgery).
  • Planned weight-loss surgery or structured weight-loss plan.

Exclusion Criteria:

  • Tobacco use within one month.
  • Qualifying lung-functioning.
  • Qualifying oxygen saturation levels.
  • Use of systemic corticosteroids (Prednisone) within one month.
  • Presence of another chronic lung disease besides asthma (COPD, bronchiectasis, ILD, sarcoidosis, etc).
  • Presence of another chronic systemic inflammatory disease (rheumatoid arthritis or other connective-tissue disease, chronic infection such as osteomyelitis, inflammatory bowel disease, chronic active hepatitis, etc). Subjects with osteoarthritis, stable coronary artery disease, hypertension, or diabetes mellitus will not be excluded.
  • Presence of malignant neoplasm within the last 3 years (with the exception of non-melanoma skin cancer).
  • Clinically significant left or right ventricular dysfunction.
  • Severe pulmonary hypertension (high blood pressure).
  • Untreated obstructive sleep apnea:
  • Subjects with a current diagnosis of sleep apnea not being treated with CPAP or BiPAP will be excluded.
  • Subjects with a current diagnosis of sleep apnea being treated adequately (as determined by the investigators) will be included.
  • Prader-Willi syndrome
  • A known endocrinopathy causing obesity (e.g., Cushing's Syndrome).

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00284895

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United States, Colorado
National Jewish Medical and Research Center
Denver, Colorado, United States, 80206
Sponsors and Collaborators
National Jewish Health
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Principal Investigator: David Beuther, MD National Jewish Medical and Research Center faculty
Layout table for additonal information Identifier: NCT00284895    
Other Study ID Numbers: NJC HS1963
First Posted: February 1, 2006    Key Record Dates
Last Update Posted: March 29, 2017
Last Verified: March 2017
Keywords provided by National Jewish Health:
Bariatric Surgery
Weight Loss Surgery
Additional relevant MeSH terms:
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Nutrition Disorders
Body Weight