Nonalcoholic Fatty Liver Disease in Taiwanese Children
Nonalcoholic fatty liver disease (NAFLD) is an emerging and important disease in Taiwan. However, the prevalence and clinical characteristics have not been studied well. The purpose of this study is to resolve the aforementioned problem.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Prevalence, Clinicopathological Characteristics, Biomarkers and Genetics of Nonalcoholic Steatohepatitis in Taiwanese Children|
- non-alcoholic fatty liver disease confirmed by liver ultrasonography [ Time Frame: one year ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Serum, WBC DNA
|Study Start Date:||January 2006|
|Estimated Study Completion Date:||December 2017|
|Estimated Primary Completion Date:||December 2015 (Final data collection date for primary outcome measure)|
[Study Subjects] Obesity was defined as the BMI value > 95 percentile by different age- and gender groups according to the standards of the Department of Health in Taiwan.
[Data Collection] The following data were obtained for each subject: age, gender, BMI, waist and hip circumference. BMI was calculated as body weight (kg)/ height (m2).
In fasting venous blood samples, we measured total serum bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, fasting glucose, triglyceride, total cholesterol,high-density lipoprotein cholesterol, insulin, glucose, and adiponectin.
[Liver Ultrasonography] All participants underwent an ultrasonographic study of the liver performed by one operator.
NAFLD was defined as the presence of an ultrasonographic pattern consistent with the following criteria: liver-kidney echo discrepancy, attenuated echo penetration and visibility of diaphragm, and obscure hepatic vessel structures.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00274183
|Contact: Yu-Cheng Lin, M.D.||886-2-89667000 ext firstname.lastname@example.org|
|Far Eastern Memorial Hospital||Recruiting|
|Taipei, Taiwan, 220|
|Contact: Yu-Cheng Lin, MD 0931122487 email@example.com|
|Principal Investigator:||Yu-Cheng Lin, M.D.||Far Eastern Memorial Hospital|