Comparison of Vasopressin and Other Pressors in Septic Shock
|ClinicalTrials.gov Identifier: NCT00269685|
Recruitment Status : Completed
First Posted : December 23, 2005
Last Update Posted : May 29, 2006
The purpose of this study is to compare the classical tactics in the treatment of septic shock (dopamine, noradrenalin and dobutamine) to the use of vasopressin as first choice pressor.
Vasopressin seems to be an interesting alternative in the treatment of septic shock. To this date, available studies have showed that it could correct hyperkinetic syndrome and vasoplegia in septic shocks without noticeable side effect. It as been demonstrated that vasopressin improves renal function, as no effect on digestive organs and as no metabolic effect.
|Condition or disease||Intervention/treatment||Phase|
|Shock, Septic||Drug: vasopressin||Phase 2 Phase 3|
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||20 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Comparative Prospective Study of Vasopressin and Catecholamine in Septic Shock|
|Study Start Date :||July 2000|
- To compare the efficiency of vasopressine to the standard and usual treatment of septic shock on the reverse of the hemodynamic criterion of septic shock
- To compare these two categories of treatment on:
- tonometric parameters
- renal function
- in term of tolerance: metabolic effects (increase in lactate and glycaemia), cardiac effects (tachycardia being defined as a heart rate increase of 15%), increase of cardiac enzymes (troponine, CK, CK-MB), and cutanuous vasoconstriction.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00269685
|Principal Investigator:||Olivier Lesur, Ph d||Centre de recherche du Centre hospitalier universitaire de Sherbrooke|