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Enhancement of Postocclusive Reactive Hyperaemia by Dipyridamole

This study has been completed.
Information provided by:
Radboud University Identifier:
First received: December 21, 2005
Last updated: March 27, 2008
Last verified: March 2008
The purpose of this study is to determine whether dipyridamole enhances postocclusive reactive hyperaemia by increasing extracellular adenosine concentrations during ischemia and reperfusion. Furthermore we hypothesize that dipyridamole augments postocclusive reactive hyperaemia by increasing adenosine receptor stimulation.

Condition Intervention
Drug: dipyridamole
Drug: caffeine

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Enhancement of Postocclusive Reactive Hyperaemia

Resource links provided by NLM:

Further study details as provided by Radboud University:

Primary Outcome Measures:
  • forearm blood flow

Estimated Enrollment: 12
Study Start Date: December 2005
Study Completion Date: July 2006

Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy volunteers between 18 and 50 years

Exclusion Criteria:

  • none specified
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Please refer to this study by its identifier: NCT00268554

Radboud university Nijmegen Medical Centre
Nijmegen, Gelderland, Netherlands, 6533 ZA
Sponsors and Collaborators
Radboud University
Principal Investigator: Gerard Rongen, MD,PhD Radboud University
  More Information Identifier: NCT00268554     History of Changes
Other Study ID Numbers: PORH-dipy 
Study First Received: December 21, 2005
Last Updated: March 27, 2008
Health Authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Keywords provided by Radboud University:

Additional relevant MeSH terms:
Vascular Diseases
Cardiovascular Diseases
Central Nervous System Stimulants
Physiological Effects of Drugs
Phosphodiesterase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
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Purinergic Antagonists
Purinergic Agents
Neurotransmitter Agents
Platelet Aggregation Inhibitors
Vasodilator Agents processed this record on October 25, 2016