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Effects of Different Assisted Mechanical Ventilation in Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS) Patients

This study has been completed.
Information provided by (Responsible Party):
Davide Chiumello, Policlinico Hospital Identifier:
First received: December 19, 2005
Last updated: April 27, 2015
Last verified: April 2015
The aim of this study is to evaluate the effects in terms of gas exchange, respiratory mechanics and comfort of breathing, of different assisted mechanical ventilation in ALI/ARDS patients.

Condition Intervention
Respiratory Distress Syndrome, Adult
Other: Mechanical Ventilation

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single Blind (Participant)
Primary Purpose: Treatment
Official Title: Effects of Different Assisted Mechanical Ventilation in ALI/ARDS Patients

Resource links provided by NLM:

Further study details as provided by Davide Chiumello, Policlinico Hospital:

Primary Outcome Measures:
  • Gas exchange and respiratory mechanics [ Time Frame: 5 minutes ]

Enrollment: 20
Study Start Date: December 2005
Study Completion Date: November 2014
Primary Completion Date: November 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
ALI/ARDS patients
Other: Mechanical Ventilation
Four different types of assisted ventilation (pressure support, pressure support plus sigh, BIPAP, variable ventilation)

Detailed Description:
ALI/ARDS patients (during assisted ventilation) will be ventilated with different types of assisted ventilation (pressure support, pressure support plus sigh, BIPAP, variable ventilation) and gas exchange, comfort of breathing, respiratory mechanics and pattern of breathing will be measured.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with ALI/ARDS

Exclusion Criteria:

  • COPD patients
  • Barotrauma
  • Hemodynamic instability
  • Age less than 18
  Contacts and Locations
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Please refer to this study by its identifier: NCT00267241

Policlinico Hospital
Milano, Italy, 20122
Sponsors and Collaborators
Policlinico Hospital
Principal Investigator: Davide Chiumello, MD Policlinico Hospital
  More Information

Responsible Party: Davide Chiumello, MD, Policlinico Hospital Identifier: NCT00267241     History of Changes
Other Study ID Numbers: 1600
Study First Received: December 19, 2005
Last Updated: April 27, 2015

Keywords provided by Davide Chiumello, Policlinico Hospital:
respiratory mechanics
gas exchange
assisted ventilation

Additional relevant MeSH terms:
Respiratory Distress Syndrome, Newborn
Respiratory Distress Syndrome, Adult
Acute Lung Injury
Pathologic Processes
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Infant, Premature, Diseases
Infant, Newborn, Diseases
Lung Injury processed this record on May 25, 2017