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Neural Changes in the Aging Auditory System

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ClinicalTrials.gov Identifier: NCT00264407
Recruitment Status : Completed
First Posted : December 12, 2005
Last Update Posted : December 12, 2005
Rochester Institute of Technology
National Institute on Aging (NIA)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Information provided by:
University of Rochester

Brief Summary:
The purpose of this study was to determine the effects of hormone replacement therapy (HRT) on hearing in post-menopausal women.

Condition or disease Intervention/treatment
Progesterone Estrogens Hearing Psychoacoustics Auditory Perceptual Disorders Drug: Hormone Replacement Therapy - HRT

Detailed Description:

Background: Female hormone influences on the development and aging of the auditory system are not completely understood. The present study retrospectively analyzed and compared hearing abilities among post-menopausal women taking hormone replacement therapy (HRT), treated with estrogen and progesterone (E+P); estrogen alone (E), and a third (control - NHRT) group, matched for age, who did not receive any HRT.

Methods: 126 subjects, (60-86 yr), N=32, E+P; N=31, E; N= 63, NHRT; matched for age and health status participated. All had relatively healthy medical histories, absence of significant noise exposure, middle ear problems, major surgeries or current/heavy smoking. Hearing tests included pure tone audiometry (PTA), tympanometry, distortion-product otoacoustic emissions (DPOAEs), transient otoacoustic emissions (TEOAEs) and hearing-in-noise-test (HINT). The latter is a test for speech perception in background noise: the major complaint of hearing-impaired persons.


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Study Type : Observational
Enrollment : 126 participants
Observational Model: Case-Control
Time Perspective: Other
Official Title: Age-Related Hearing Loss: Presbycusis & Its Neural Bases
Study Start Date : January 2001
Study Completion Date : February 2005

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Ages Eligible for Study:   60 Years to 86 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy middle ears

Exclusion Criteria:

  • ototoxic medications
  • serious medical health problems
  • neurological conditions
  • Meniere's disease or labyrinthitis
  • those who failed cognitive screening tests (Mini-Mental Test)
  • current/heavy smokers
  • conductive hearing loss
  • history of noise damage and/or audiograms signifying noise damage
  • poor speech discrimination scores (80% or less)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00264407

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United States, New York
International Center Hearing & Speech Research - NTID - RIT
Rochester, New York, United States, 14623-5604
University of Rochester Medical Center
Rochester, New York, United States, 14642
Sponsors and Collaborators
University of Rochester
Rochester Institute of Technology
National Institute on Aging (NIA)
National Institute on Deafness and Other Communication Disorders (NIDCD)
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Study Director: Robert D Frisina, Ph.D. University of Rochester Medical School
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ClinicalTrials.gov Identifier: NCT00264407    
Other Study ID Numbers: 10121
P01AG009524 ( U.S. NIH Grant/Contract )
First Posted: December 12, 2005    Key Record Dates
Last Update Posted: December 12, 2005
Last Verified: December 2005
Keywords provided by University of Rochester:
Hearing Loss, Central
Hearing Loss, Sensorineural
Hearing Loss, Cochlear
Hearing Loss, Bilateral
Sex Steroid Hormones
Additional relevant MeSH terms:
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Hearing Loss
Auditory Perceptual Disorders
Perceptual Disorders
Hearing Disorders
Ear Diseases
Otorhinolaryngologic Diseases
Sensation Disorders
Neurologic Manifestations
Nervous System Diseases
Neurobehavioral Manifestations
Auditory Diseases, Central
Retrocochlear Diseases
Brain Diseases
Central Nervous System Diseases
Cognition Disorders
Neurocognitive Disorders
Mental Disorders
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs