Optimal Pharmacological Therapy In Implantable Defibrillator Patients (OPTIC)

This study has been completed.
St. Jude Medical
Information provided by:
Connolly, Stuart, M.D.
ClinicalTrials.gov Identifier:
First received: November 22, 2005
Last updated: July 26, 2006
Last verified: November 2005
This is an open parallel design randomized trial of amiodarone plus a beta blocker vs a beta blocker alone vs sotalol for the prevention of ICD shocks in patients receiving an ICD for spontaneous or inducible ventricular tachycardia or fibrillation

Condition Intervention Phase
Ventricular Tachycardia
Drug: amiodarone beta blocker sotalol
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention

Resource links provided by NLM:

Further study details as provided by Connolly, Stuart, M.D.:

Primary Outcome Measures:
  • ICD shock for any cause

Estimated Enrollment: 400
Study Start Date: January 2001
Estimated Study Completion Date: October 2004

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria: spontaneous or inducible ventricular tachycardia or fibrillation -

Exclusion Criteria:

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Please refer to this study by its ClinicalTrials.gov identifier: NCT00257959

Canada, Ontario
McMaster University
Hamilton, Ontario, Canada
Sponsors and Collaborators
Connolly, Stuart, M.D.
St. Jude Medical
Principal Investigator: Stuart Connolly McMaster University
  More Information

ClinicalTrials.gov Identifier: NCT00257959     History of Changes
Other Study ID Numbers:
Study First Received: November 22, 2005
Last Updated: July 26, 2006
Health Authority: Canada: Ethics Review Committee

Additional relevant MeSH terms:
Tachycardia, Ventricular
Arrhythmias, Cardiac
Cardiovascular Diseases
Heart Diseases
Pathologic Processes
Adrenergic beta-Antagonists
Adrenergic Agents
Adrenergic Antagonists
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Pharmacologic Actions
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on February 11, 2016