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Morphofunctional Imaging and Developmental Dyslexia (PHR04-CH/DYS)

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ClinicalTrials.gov Identifier: NCT00254644
Recruitment Status : Completed
First Posted : November 16, 2005
Last Update Posted : January 16, 2017
Information provided by (Responsible Party):
University Hospital, Tours

Brief Summary:
Developmental dyslexia is a frequent learning disability. The aim of this study is to analyze cortical thickness and phonological treatment in right handed adults with developmental dyslexia. They are compared to control adults paired with age and laterality. To study phonological treatment, the researchers used functional magnetic resonance imaging (fMRI) with a rime judgement task and silent word generation.

Condition or disease Intervention/treatment
Developmental Dyslexia Procedure: Morphological and functional MRI

Study Type : Observational
Actual Enrollment : 32 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Morphofunctional Imaging and Developmental Dyslexia
Study Start Date : February 2007
Primary Completion Date : February 2008
Study Completion Date : February 2008

Group/Cohort Intervention/treatment
adults from 18-35 ans.
Procedure: Morphological and functional MRI
one time
adults from 18-35 ans.
Procedure: Morphological and functional MRI
one time

Primary Outcome Measures :
  1. Cortical thickness [ Time Frame: 2 years ]
    The average cortical thickness maps of healthy subjects and dyslexic will be compared hemisphere by hemisphere. This will identify whether there are cortical areas including cortical thickness differed significantly between normal and dyslexic.ts of different ages

Secondary Outcome Measures :
  1. Average cortical thickness [ Time Frame: 2 years ]
    For each group, cortical thickness maps of average left and right hemispheres are compared. This will identify whether there is an asymmetry left / right in terms of cortical thickness in normal subjects and dyslexic.

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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
This is a prospective study including 15 right-handed male subjects, aged 18 to 35 years, carrying a developmental dyslexia and 15 control subjects handed the same sex. We chose to include only male subjects to obtain a homogeneous population and to avoid the problem of a functional organization differs according to gender.

Inclusion Criteria:

  • Developmental dyslexia according to Critchley.
  • Normal performance intelligence quotient (PIQ)
  • Age: 18-35 years
  • Sex: Male
  • Right handed
  • No hearing deficit.

Exclusion Criteria:

  • No head injury
  • No attention deficit hyperactivity disorder (ADHD)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00254644

Tours, France, 37044
Sponsors and Collaborators
University Hospital, Tours
Principal Investigator: Frédérique Bonnet-Brilhault CHU Tours

Responsible Party: University Hospital, Tours
ClinicalTrials.gov Identifier: NCT00254644     History of Changes
Other Study ID Numbers: PHRR04-CH/DYS
First Posted: November 16, 2005    Key Record Dates
Last Update Posted: January 16, 2017
Last Verified: May 2011

Keywords provided by University Hospital, Tours:
phonological treatment

Additional relevant MeSH terms:
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Learning Disorders
Signs and Symptoms
Neurodevelopmental Disorders
Mental Disorders