Spinal Anesthesia With Articaine and Lidocaine for Outpatient Surgery.
The purpose of this study is to compare two short-acting local anesthetics, articaine and lidocaine, for spinal anesthesia in day-case surgery. The onset time of the sensory- and motor block, recovery time until discharge and complications will be studied.
Drug: spinal administration of articaine
Drug: spinal administration of lidocaine
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
|Official Title:||Spinal Anesthesia With Articaine and Lidocaine for Outpatient Surgery: A Double Blind Randomized Clinical Trial.|
- Onset time (sec) of sensory and motor blockade (after administration of drug)
- Recovery time (min) from sensory and motor blockade
- Spread of sensory blockade (30 min after administration of drug, dermatomal level)
- Hemodynamic stability (lowest systolic blood pressure, vasopressor therapy)
- Patient satisfaction
|Study Start Date:||November 2005|
|Estimated Study Completion Date:||May 2006|
|Active Comparator: lidocaine||Drug: spinal administration of lidocaine|
|Experimental: articaine||Drug: spinal administration of articaine|
The ideal spinal anesthesia in day-case surgery is characterized by a short onset of sensory and motor blockade, and a rapid recovery after the operation. Short-acting local-anesthetics are used frequently in this setting.
Lidocaine is one of the agents that is used most frequently. It has been associated with an increased incidence of Transient Neurological Symptoms (TNS). Articaine is another agent that is being used more often and is said to act faster and shorter than lidocaine.
We will compare spinal anesthesia with lidocaine and articaine in a randomized double-blind clinical trial. Endpoint are:
- onset of sensory and motor block
- recovery from sensory and motor block
- time to micturition
- patient satisfaction
Please refer to this study by its ClinicalTrials.gov identifier: NCT00247741
|St Antonius Hospital|
|Nieuwegein, Utrecht, Netherlands, 3435 CM|
|Principal Investigator:||Leon Timmerman, MD||St Antonius Hospital, dept. of anesthesiology|
|Study Chair:||Emile MJ Andriessen, MD||St Antonius Hospital, dept of anesthesiology|