Circadian Rhythms and Sleep in Familial DSPS and ASPS
|Circadian Rhythm Sleep Disorder|
|Official Title:||Circadian Rhythms and Sleep in Familial Delayed Sleep Phase Syndrome (DSPS) and Advanced Sleep Phase Syndrome (ASPS)|
- Sleep [ Time Frame: 1 night ]Assessment of sleep parameters
- Circadian Timing [ Time Frame: 3 days ]Assessment of circadian activity profiles
Biospecimen Retention: Samples Without DNA
|Study Start Date:||September 2003|
|Estimated Study Completion Date:||September 2017|
|Estimated Primary Completion Date:||September 2017 (Final data collection date for primary outcome measure)|
People with delayed sleep phase syndrome (DSPS).
People with advanced sleep phase syndrome (ASPS).
Control group (people with intermediate sleep patterns).
Tremendous progress in the past few years has led to the identification of several circadian clock genes. This now makes it possible to determine how alterations of human circadian clock genes and their expression could lead to differences in circadian and sleep/wake cycle phenotypes. Of particular interest for understanding genetics of the human circadian system are individuals with sleep phase disorders, such as DSPS and advanced sleep phase syndrome (ASPS), because recent studies indicate a genetic basis for these disorders. While it is assumed that both ASPS and DSPS are disorders of circadian timing, little is known about how the circadian clock system, or its interaction with sleep processes, are affected in these individuals.
Participants will complete questionnaires and actigraphy to determine sleep patterns and quality.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00246454
|Contact: Sabra Abbott, MD, PhDfirstname.lastname@example.org|
|United States, Illinois|
|Chicago, Illinois, United States, 60611|
|Contact: Sabra Abbott 312-503-3561 email@example.com|
|Principal Investigator: Phyllis C. Zee, MD, PhD|
|Principal Investigator:||Phyllis C. Zee, MD, PhD||Northwestern University|