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Redistribution of Fat and Metabolic Change in HIV Infection: Protocol 2 (FRAM Fat 2)

This study has been completed.
National Institutes of Health (NIH)
Information provided by (Responsible Party):
Johns Hopkins University Identifier:
First received: October 25, 2005
Last updated: August 30, 2016
Last verified: August 2016
The purpose of this study is to learn whether HIV-infected patients have blood abnormalities which could lead to heart attack or stroke, and to find out what factors may contribute to these abnormalities.

Human Immunodeficiency Virus

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Redistribution and Metabolic Change in HIV Infection: Protocol 2 (FRAM Fat 2)

Resource links provided by NLM:

Further study details as provided by Johns Hopkins University:

Enrollment: 101
Study Start Date: January 2005
Study Completion Date: May 2007
Primary Completion Date: May 2007 (Final data collection date for primary outcome measure)
HIV Positive FRAM 1 Participant

Detailed Description:

This research is being done to learn whether HIV-infected patients have abnormalities in their blood vessels that could eventually lead to heart attack or stroke (atherosclerosis), in how fat is distributed in their body and in how their body handles fat and sugars. If there are abnormalities, this study will also try to find out what factors may contribute to those abnormalitites.

People who participated in FRAM 1 may join FRAM 2.


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
men or women 18-65 years old, previous FRAM 1 participant, HIV positive

Inclusion Criteria:

  • 18-65 years old
  • previous FRAM 1 participant
  • HIV positive

Exclusion Criteria:

  • Artificial knee or hip replacement or Harrington rod
  • Metal objects in the body.Pregnancy
  • Breastfeeding or less than 3 months after breastfeeding
  • Weight more than 300 pound
  • On insulin, pancreatic enzymes, or thioridazine.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00244803

United States, Maryland
Johns Hopkins University, The Clinical Trials Unit
Baltimore, Maryland, United States, 21205
Sponsors and Collaborators
Johns Hopkins University
National Institutes of Health (NIH)
Principal Investigator: Joseph Cofrancesco Jr., M.D. Johns Hopkins University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Johns Hopkins University Identifier: NCT00244803     History of Changes
Other Study ID Numbers: 03-07-02-01
Study First Received: October 25, 2005
Last Updated: August 30, 2016

Keywords provided by Johns Hopkins University:
Human Immunodeficiency Virus

Additional relevant MeSH terms:
HIV Infections
Acquired Immunodeficiency Syndrome
Immunologic Deficiency Syndromes
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immune System Diseases
Slow Virus Diseases processed this record on May 25, 2017