Effect of CPAP (Continuous Positive Airway Pressure) on Lung Function in Asthmatics With Sleep Apnea
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|ClinicalTrials.gov Identifier: NCT00238069|
Recruitment Status : Completed
First Posted : October 13, 2005
Last Update Posted : March 29, 2017
|Condition or disease||Intervention/treatment||Phase|
|Asthma Sleep Apnea||Device: CPAP machine as a result of sleep study||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||20 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Effect of CPAP (Continuous Positive Airway Pressure) on Airway Inflammation in Asthmatics With Sleep-Disordered Breathing: A Pilot Study|
|Study Start Date :||December 2004|
|Actual Primary Completion Date :||August 2005|
|Actual Study Completion Date :||August 2005|
- Systemic inflammatory markers will include IL-6, IL-8, CRP, and TNF-α.
- Exhaled breath condensate levels of IL-6 and 8-isporostane will be measured.
- BAL (bronchial lavage) fluid cell count and differential, IL-6, IL-8, and TNF- α will be measured.
- Endobronchial biopsies to analyze extent and type of inflammatory cell.
- Symptoms, albuterol use and daily morning and evening peak expiratory flows from diary cards.
- Spirometry measured at three time points: before, during, and after CPAP therapy.
- Post-CPAP methacholine for bronchial hyperreactivity
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00238069
|United States, Colorado|
|National Jewish Medical and Research Center|
|Denver, Colorado, United States, 80206|
|Principal Investigator:||Richard Martin, MD||National Jewish Medical and Research Center faculty|