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Effects of Anemia Correction on Vascular and Monocyte Function in Renal Transplant Recipients

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ClinicalTrials.gov Identifier: NCT00204334
Recruitment Status : Completed
First Posted : September 20, 2005
Last Update Posted : January 13, 2010
Sponsor:
Collaborator:
Amgen
Information provided by:
University Hospital Muenster

Brief Summary:

Correction of anaemia in renal transplant recipients by parenteral application of recombinant erythropoietin and if necessary iron will improve large artery function (endothelial function and elasticity), as assessed by ultrasound techniques and applanation tonometry.

The changes in large artery function will be reflected by changes in serological markers of endothelial function and oxidative stress and by changes in monocyte function and apoptosis.

There are gender differences in the responses of vascular function to correction of anemia.

Besides improvement of large artery function, correction of anemia will also affect parameters of graft function, i.e. glomerular and tubular proteinuria.


Condition or disease Intervention/treatment Phase
Kidney Transplantation Anemia Drug: darbopoeitin Phase 4

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 60 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Effects of Anemia Correction on Vascular Function, Endothelial Cell Markers and Monocyte Apoptosis in Renal Transplant Recipients
Study Start Date : June 2005
Actual Primary Completion Date : January 2010
Actual Study Completion Date : January 2010

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Vessel wall stiffness

Secondary Outcome Measures :
  1. expression of endothelial cell markers


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

kidney transplant recipient stable kidney function Hb between 10mg/ml and 10.5mg/ml

Exclusion Criteria:

acute rejection Hb above 12.0mg/dl


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00204334


Locations
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Germany
UKM
Münster, NRW, Germany, 48149
Sponsors and Collaborators
University Hospital Muenster
Amgen
Investigators
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Principal Investigator: Martin Hausberg, MD UKM- Medical Department D
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Responsible Party: University Hospital Muenster
ClinicalTrials.gov Identifier: NCT00204334    
Other Study ID Numbers: Haus_Lang-Endothel-Mono-Hb
DE-2004-4077
First Posted: September 20, 2005    Key Record Dates
Last Update Posted: January 13, 2010
Last Verified: May 2008
Keywords provided by University Hospital Muenster:
Kidney transplantation
anemia
vascular endothelium
monocytes
apoptosis
Additional relevant MeSH terms:
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Anemia
Hematologic Diseases