Study on Amino Acid Uptake in Brain Tumors
|ClinicalTrials.gov Identifier: NCT00204295|
Recruitment Status : Unknown
Verified September 2006 by University Hospital Muenster.
Recruitment status was: Active, not recruiting
First Posted : September 20, 2005
Last Update Posted : September 14, 2006
|Condition or disease||Intervention/treatment||Phase|
|Brain Neoplasms||Drug: O-(2-[F-18]Fluorethyl)-L-Tyrosin (FET) - PET||Phase 2|
Radioactively labelled amino acids have been used for years to delineate primary brain tumors and for the early detection of tumor recurrence. Positron emission tomography studies indicate that the extent of amino acid uptake correlates to the true histological extent of gliomas. Recently a fluorine-18 labelled amino acid has been introduced (O-(2-[F-18]Fluorethyl)-L-tyrosin (FET)), which is suitable for routine use in brain tumor patients. There is evidence that this amino acid is transported into brain and brain tumors by the amino acid transport of the L-type. The cDNA of this L-transporter has recently been cloned and has been shown to be identical to the light chain of the 4F2-antigen (CD98), which has previously been described as marker of cell growth and proliferation.
The heavy chain of this heterodimer is known to modulate integrins which are thought to play a fundamental role in glioma invasion.
Besides the evaluation of the diagnostic capability of FET in brain tumors, a comparison of FET uptake in vivo and CD98 expression ex-vivo is performed with tissue slices as available after routine surgery in glioma patients.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||60 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Phase 2 Study on Brain Tumor Uptake of the Amino Acid O-(2-[F-18]Fluorethyl)-L-Tyrosin (FET)|
|Study Start Date :||January 2004|
- Histological samples where available
- CD98 staining where available
- Clinical follow-up for at least one year
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00204295
|Department of Nuclear Medicine, University Hospital Muenster|
|Muenster, NRW, Germany, D-48149|
|Principal Investigator:||Matthias Weckesser, MD||Department of Nuclear Medicine, University Hospital Muenster|