Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected Subjects - Full Text View

Purpose

Magnetic resonance spectroscopy (MRS) is commonly applied in medicine with 1H proton or 31-phosphorus spectra. The proton MRS is often used in evaluating the central nervous system and 31P MRS is used in muscular diseases or neoplasms. However, the proton MRS is also considered to be applied to the musculoskeletal system because of its profound amount of protons. Ballon used the STEAM technique, and Schick used the PRESS technique, to investigate the lipid and water spectra of the bone marrow and also correlated those with hematological diseases and post-treatment effects. Schellinger et al. used the STEAM sequence to calculate the lipid content of the vertebral bone marrow and found that it was influenced according to age and sex. The investigator had used the proton MRS to evaluate the lipid and water spectra of the femoral head and revealed its significance in predicting avascular necrosis of the femoral head. According to the above research literature, the investigators considered further investigation of the proton MRS in evaluating the musculoskeletal system.

Condition	Phase
Acquired Immunodeficiency Syndrome Lipodystrophy	Phase 3


Study Type:	Observational
Study Design:	Observational Model: Defined Population Time Perspective: Cross-Sectional
Official Title:	Proton Magnetic Resonance Spectroscopy (1H MRS) in Evaluating the Bone Marrow, Muscle and Adipose Tissue on Normal and Human Immunodeficiency Virus Infected Subjects, With Serial Follow-Up

Resource links provided by NLM:

MedlinePlus related topics: HIV/AIDS

Genetic and Rare Diseases Information Center resources: Lipodystrophy Sphingolipidosis

U.S. FDA Resources

Further study details as provided by National Taiwan University Hospital:


Study Start Date:	December 2003

Detailed Description:

Magnetic resonance spectroscopy (MRS) is commonly applied in medicine with 1H proton or 31-phosphorus spectra. The proton MRS is often used in evaluating the central nervous system and 31P MRS is used in muscular diseases or neoplasms. However, the proton MRS is also considered to be applied to the musculoskeletal system because of its profound amount of protons. Ballon used the STEAM technique, and Schick used the PRESS technique, to investigate the lipid and water spectra of the bone marrow and also correlated those with hematological diseases and post-treatment effects. Schellinger et al. used the STEAM sequence to calculate the lipid content of the vertebral bone marrow and found that it was influenced according to age and sex. The investigator had used the proton MRS to evaluate the lipid and water spectra of the femoral head and revealed its significance in predicting avascular necrosis of the femoral head. According to the above research literature, the investigators considered further investigation of the proton MRS in evaluating the musculoskeletal system.

Eligibility


Ages Eligible for Study:	20 Years to 70 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Patients with a diagnosis of acquired immunodeficiency syndrome (AIDS)
Normal volunteers

Exclusion Criteria:

AIDS patients with newly developed neoplasms

Contacts and Locations

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00172315

Locations


Taiwan
Tiffany Ting-Fang Shih	Recruiting
Taipei, Taiwan
Contact: Tiffany Ting-Fang Shih, M.D. 886-2-23123456 ext 6993 ttfshih@ha.mc.ntu.edu.tw

Sponsors and Collaborators

National Taiwan University Hospital

Investigators


Principal Investigator:	Tiffany Ting-Fang Shih, M.D.	Department of Medical Imaging, National Taiwan University Hospital

More Information

No publications provided


ClinicalTrials.gov Identifier:	NCT00172315 History of Changes
Other Study ID Numbers:	9261701422
Study First Received:	September 12, 2005
Last Updated:	March 28, 2006
Health Authority:	Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:


acquired immunodeficiency syndrome lipodystrophy MR spectroscopy

Additional relevant MeSH terms:


Acquired Immunodeficiency Syndrome HIV Infections Immunologic Deficiency Syndromes Lipodystrophy Immune System Diseases Lentivirus Infections Lipid Metabolism Disorders Metabolic Diseases	RNA Virus Infections Retroviridae Infections Sexually Transmitted Diseases Sexually Transmitted Diseases, Viral Skin Diseases Skin Diseases, Metabolic Slow Virus Diseases Virus Diseases

ClinicalTrials.gov processed this record on February 27, 2015