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Angiotensin Converting Enzyme Gene Polymorphism in Children With Idiopathic Nephrotic Syndrome

This study has been completed.
Information provided by:
National Taiwan University Hospital Identifier:
First received: September 12, 2005
Last updated: September 14, 2005
Last verified: June 2005

Aims This study was conducted to examine the association between the ACE insertion/deletion (I/D) genotype distribution in children with idiopathic nephrotic syndrome and the response to steroid therapy.

Patients and Methods The patients with idiopathic nephrotic syndrome were divided into 2 groups according to their clinical response to steroid: SS group including infrequent and frequent relapsers and non-SS group including steroid resistant (SR) and steroid dependent (SD) patients. Children without previous renal diseases and negative proteinuria were enrolled as control group in genetic study. The genotypes for ACE gene I/D polymorphism including DD, ID and II were analyzed by the newly developed automatic denaturing high performance liquid chromatography system (DHPLC).

Nephrotic Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Retrospective

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:


Ages Eligible for Study:   1 Year to 10 Years   (Child)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • Total 59 children diagnosed as nephrotic syndrome at the age of 1 to 10 year-old were recruited in this study. These children with nephrotic syndrome were under follow-up at the Pediatric Nephrology Clinic in National Taiwan University Hospital. In addition, children without previous renal diseases and negative proteinuria were enrolled as control group in genetic study.
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Please refer to this study by its identifier: NCT00172276

Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Yong-Kwei Tsau, MD National Taiwan University Hospital
  More Information Identifier: NCT00172276     History of Changes
Other Study ID Numbers: 9261701241
Study First Received: September 12, 2005
Last Updated: September 14, 2005

Additional relevant MeSH terms:
Nephrotic Syndrome
Pathologic Processes
Kidney Diseases
Urologic Diseases processed this record on April 28, 2017