The Effect of Liberal vs. Restrictive Transfusion Strategies on Rehabilitation After Hip Fracture Surgery
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ClinicalTrials.gov Identifier: NCT00162617
Verified September 2006 by Hvidovre University Hospital. Recruitment status was: Active, not recruiting
To examine the effect of two different transfusion regimens on rehabilitation after hip fracture surgery.
Condition or disease
Drug: Red blood cell transfusion
The effect of liberal vs restrictive transfusion regimens after hip fracture surgery is unresolved. Liberal transfusion regimens (transfusion trigger hgb. 6.25 mmol/l) leads to an increased use of blood products but may impact positively on rehabilitation outcome, a restrictive transfusion trigger (hbg. 5.0 mmol/l) saves blood products but may also impair postoperative rehabilitation and outcome. the study randomizes 120 elderly patients with hip fractures to either a restrictive or a liberal perioperative transfusion therapy and measures postoperative rehabilitation outcomes within a well defined multimodal rehabilitation regimen.
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Ages Eligible for Study:
65 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Primary hip fracture
capable of informed consent
able to ambulate independent of human assistance
no active heart condition defined as no AMI within 3 months, no unstable angina or present incompensation/pulmonary oedema
no regular transfusion demand or terminal disease.
postop. immobilization due to to surgical reasons
patient refusal to participate in relevant rehabilitation