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GR Defect in Peripheral Blood Mononuclear Cells in COPD

This study has been completed.
Information provided by:
Imperial College London Identifier:
First received: September 8, 2005
Last updated: August 12, 2008
Last verified: August 2008
  Purpose investigate a possible mechanism of the glucocorticosteroid receptors (GR) defect in patients with severe COPD by studying the effect of dexamethasone (Dex) on GR- binding, interleukin production (IL-6/IL-8) and MKP-1 expression in peripheral blood mononuclear cells blood (PBMC)

Condition Intervention
Chronic Obstructive Pulmonary Disease Procedure: blood test

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: GR Defect in Peripheral Blood Mononuclear Cells in COPD

Further study details as provided by Imperial College London:

Estimated Enrollment: 30
Study Start Date: February 2005
Estimated Study Completion Date: December 2008

Ages Eligible for Study:   35 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • Patients with severe (stage III, Gold) to very severe (stage IV, GOLD) COPD or subjects who are healthy smokers or subjects who are non-smokers
  • Written informed consent

Exclusion Criteria:

  • Current upper respiratory tract infections
  • Any significant disease or disorder (e.g. cardiovascular, pulmonary (other than asthma), gastrointestinal, liver, renal, neurological, musculoskeletal, endocrine, metabolic, malignant, psychiatric, major physical impairment) which, in the opinion of the investigator, may either put the subject at risk because of participation in the study, or may influence the results of the study, or the subjects ability to participate in the study
  • Subjects not considered capable, as judged by the investigator, of following instructions of the study, e.g. because of a history of alcohol or drug abuse or any other reason
  Contacts and Locations
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Please refer to this study by its identifier: NCT00159237

United Kingdom
Section of Airway Disease, Asthma Lab, Imperial College London, Royal Brompton Hospital
London, United Kingdom, SW3 6LY
Sponsors and Collaborators
Imperial College London
Principal Investigator: Sergei A Kharitonov, MD PhD Imperial College London
  More Information Identifier: NCT00159237     History of Changes
Other Study ID Numbers: D5899N00007
Study First Received: September 8, 2005
Last Updated: August 12, 2008

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases processed this record on September 21, 2017