Analysis of Genetic Factors Which May Influence the Course of HIV Infection
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| ClinicalTrials.gov Identifier: NCT00159068 |
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Recruitment Status :
Completed
First Posted : September 12, 2005
Last Update Posted : August 10, 2017
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Sponsor:
Deborah Rund
Information provided by (Responsible Party):
Deborah Rund, Hadassah Medical Organization
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Brief Summary:
Patients with HIV an have a variable course of their infection. We are trying to identify factors which worsen or ameliorate the course of the disease. Such factors may be related to metabolism (breakdown) of drugs or to iron handling by the body.
| Condition or disease |
|---|
| HIV Infection |
Patients with HIV can have a variable course and the disease may be influenced by polymorphisms in drug metabolism and disposition genes such as MDR1 and CYP3A4. In addition, reports have linked changes in the course of the disease with iron status, with high iron being detrimental. We will study polymorphisms in these genes and correlate with clinical course in HIV patients and also with phenotype of drug resistance and disease parameters (such as CD4 counts and opportunistic infections).
| Study Type : | Observational |
| Actual Enrollment : | 100 participants |
| Observational Model: | Other |
| Time Perspective: | Prospective |
| Official Title: | Genetic Influences on the Course and Response to Treatment of HIV: Contribution of Polymorphisms in Drug Metabolism and Disposition Genes and Haptoglobin Polymorphisms |
| Study Start Date : | February 2004 |
| Actual Primary Completion Date : | April 2011 |
| Actual Study Completion Date : | April 2011 |
Biospecimen Retention: Samples With DNA
DNA isolated from peripheral blood.
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| Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Study Population
Patients with HIV attending the HIV clinic at Hadassah colden globes.
Criteria
Inclusion Criteria:
- diagnosis of HIV
Exclusion Criteria:
- under 18 years of age
Information from the National Library of Medicine
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00159068
Locations
| Israel | |
| Hadassah Medical Organization | |
| Jerusalem, Israel, IL91120 | |
Sponsors and Collaborators
Deborah Rund
Investigators
| Principal Investigator: | Deborah Rund, MD | Hadassah Medical Organization |
Publications:
| Responsible Party: | Deborah Rund, Senior Hematologist, Hadassah Medical Organization |
| ClinicalTrials.gov Identifier: | NCT00159068 History of Changes |
| Other Study ID Numbers: |
391200-HMO-CTIL |
| First Posted: | September 12, 2005 Key Record Dates |
| Last Update Posted: | August 10, 2017 |
| Last Verified: | August 2017 |
Additional relevant MeSH terms:
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Infection HIV Infections Acquired Immunodeficiency Syndrome Lentivirus Infections Retroviridae Infections RNA Virus Infections |
Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immunologic Deficiency Syndromes Immune System Diseases Slow Virus Diseases |