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Analysis of Genetic Factors Which May Influence the Course of HIV Infection
This study has been completed.
Sponsor:
Hadassah Medical Organization
Information provided by:
Hadassah Medical Organization
ClinicalTrials.gov Identifier:
NCT00159068
First received: September 9, 2005
Last updated: June 22, 2011
Last verified: June 2010
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Purpose
Patients with HIV an have a variable course of their infection. We are trying to identify factors which worsen or ameliorate the course of the disease. Such factors may be related to metabolism (breakdown) of drugs or to iron handling by the body.
| Condition |
|---|
| HIV Infection |
| Study Type: | Observational |
| Study Design: | Time Perspective: Prospective |
| Official Title: | Genetic Influences on the Course and Response to Treatment of HIV: Contribution of Polymorphisms in Drug Metabolism and Disposition Genes and Haptoglobin Polymorphisms |
Resource links provided by NLM:
Further study details as provided by Hadassah Medical Organization:
Biospecimen Retention: Samples With DNA
Detailed Description:
DNA isolated from peripheral blood.
| Estimated Enrollment: | 150 |
| Study Start Date: | February 2004 |
| Study Completion Date: | April 2011 |
| Primary Completion Date: | April 2011 (Final data collection date for primary outcome measure) |
Patients with HIV can have a variable course and the disease may be influenced by polymorphisms in drug metabolism and disposition genes such as MDR1 and CYP3A4. In addition, reports have linked changes in the course of the disease with iron status, with high iron being detrimental. We will study polymorphisms in these genes and correlate with clinical course in HIV patients and also with phenotype of drug resistance and disease parameters (such as CD4 counts and opportunistic infections).
Eligibility| Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
| Sexes Eligible for Study: | All |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Study Population
Patients with HIV attending the HIV clinic at Hadassah colden globes.
Criteria
Inclusion Criteria:
- diagnosis of HIV
Exclusion Criteria:
- under 18 years of age
Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00159068
Please refer to this study by its ClinicalTrials.gov identifier: NCT00159068
Locations
| Israel | |
| Hadassah Medical Organization | |
| Jerusalem, Israel, IL91120 | |
Sponsors and Collaborators
Hadassah Medical Organization
Investigators
| Principal Investigator: | Deborah Rund, MD | Hadassah Medical Organization |
More Information
Publications:
| Responsible Party: | Deborah Rund, Hadassah Medical Organization |
| ClinicalTrials.gov Identifier: | NCT00159068 History of Changes |
| Other Study ID Numbers: |
391200-HMO-CTIL |
| Study First Received: | September 9, 2005 |
| Last Updated: | June 22, 2011 |
Additional relevant MeSH terms:
|
Infection HIV Infections Acquired Immunodeficiency Syndrome Lentivirus Infections Retroviridae Infections RNA Virus Infections |
Virus Diseases Sexually Transmitted Diseases, Viral Sexually Transmitted Diseases Immunologic Deficiency Syndromes Immune System Diseases Slow Virus Diseases |
ClinicalTrials.gov processed this record on June 23, 2017