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Analysis of Genetic Factors Related to Predisposition and Prognosis of Hematological Malignancies in Israel

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00159003
First Posted: September 12, 2005
Last Update Posted: August 10, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Deborah Rund, Hadassah Medical Organization
  Purpose

There are naturally occuring variations in the genetic makeup of all of us. Some of these variations may contribute to a change in susceptibility toward different diseases or change the prognosis.

We are studying these genetic variations in patients with leukemia. The genes we are studying are those which influence detoxification of drugs and toxins.


Condition
Acute Myeloid Leukemia Chronic Lymphocytic Leukemia Chronic Myelogenous Leukemia

Study Type: Observational
Study Design: Observational Model: Other
Time Perspective: Prospective
Official Title: Molecular Analysis of Genetic Elements Which May Influence Predisposition and Prognosis of Hematological Malignancies in Different Ethnic Groups in Israel

Resource links provided by NLM:


Further study details as provided by Deborah Rund, Hadassah Medical Organization:

Biospecimen Retention:   Samples With DNA
DNA only

Enrollment: 100
Actual Study Start Date: January 1, 1998
Study Completion Date: July 1, 2017
Primary Completion Date: July 1, 2017 (Final data collection date for primary outcome measure)
Detailed Description:

We have prepared DNA on patients with leukemia (AML, CML and CLL) and we are studying the influence of polymorphisms in drug metabolism and disposition genes on predisposition and prognosis of these types of leukemia. The genes we are studying include: MDR1, CYP3A4, NQO1, NAT1/2, GST, hOCT. We plan to study other genes that may be contributory.

Study includes comparing the frequency of polymorphisms in these genes with the frequency in the general population and the study of DNA biding proteins which bind at the sites of these polymorphisms.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients admitted to Hadassah Hospital with AML or CLL.
Criteria

Inclusion Criteria:

  • diagnosis of acute myeloid leukemia or chronic lymphocytic leukemia

Exclusion Criteria:

  • under 18 years of age
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00159003


Locations
Israel
Hadassah Medical Organization
Jerusalem, Israel, IL91120
Sponsors and Collaborators
Deborah Rund
Investigators
Principal Investigator: Deborah G Rund, MD Hadassah Medical Organization
  More Information

Publications:
Responsible Party: Deborah Rund, Senior Hematologist, Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT00159003     History of Changes
Other Study ID Numbers: 132910-HMO-CTIL
First Submitted: September 8, 2005
First Posted: September 12, 2005
Last Update Posted: August 10, 2017
Last Verified: August 2017

Keywords provided by Deborah Rund, Hadassah Medical Organization:
drug metabolism and disposition enzymes

Additional relevant MeSH terms:
Leukemia
Leukemia, Myeloid, Acute
Leukemia, Lymphoid
Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, Myeloid
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Disease Susceptibility
Neoplasms by Histologic Type
Neoplasms
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Leukemia, B-Cell
Myeloproliferative Disorders
Bone Marrow Diseases
Hematologic Diseases
Disease Attributes
Pathologic Processes