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Analysis of Genetic Factors Related to Predisposition and Prognosis of Hematological Malignancies in Israel

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified June 2011 by Hadassah Medical Organization.
Recruitment status was:  Recruiting
Information provided by:
Hadassah Medical Organization Identifier:
First received: September 8, 2005
Last updated: June 22, 2011
Last verified: June 2011

There are naturally occuring variations in the genetic makeup of all of us. Some of these variations may contribute to a change in susceptibility toward different diseases or change the prognosis.

We are studying these genetic variations in patients with leukemia. The genes we are studying are those which influence detoxification of drugs and toxins.

Acute Myeloid Leukemia
Chronic Lymphocytic Leukemia
Chronic Myelogenous Leukemia

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Molecular Analysis of Genetic Elements Which May Influence Predisposition and Prognosis of Hematological Malignancies in Different Ethnic Groups in Israel

Resource links provided by NLM:

Further study details as provided by Hadassah Medical Organization:

Biospecimen Retention:   Samples With DNA
DNA only

Estimated Enrollment: 300
Study Start Date: January 1998
Estimated Study Completion Date: April 2012
Detailed Description:

We have prepared DNA on patients with leukemia (AML, CML and CLL) and we are studying the influence of polymorphisms in drug metabolism and disposition genes on predisposition and prognosis of these types of leukemia. The genes we are studying include: MDR1, CYP3A4, NQO1, NAT1/2, GST, hOCT. We plan to study other genes that may be contributory.

Study includes comparing the frequency of polymorphisms in these genes with the frequency in the general population and the study of DNA biding proteins which bind at the sites of these polymorphisms.


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients admitted to Hadassah Hospital with AML or CLL.

Inclusion Criteria:

  • diagnosis of acute myeloid leukemia or chronic lymphocytic leukemia

Exclusion Criteria:

  • under 18 years of age
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00159003

Contact: Deborah G Rund, MD 972-2-6778712

Hadassah Medical Organization Recruiting
Jerusalem, Israel, IL91120
Contact: Deborah G Rund, MD    972-2-6778712   
Principal Investigator: Deborah G Rund, MD         
Sponsors and Collaborators
Hadassah Medical Organization
Principal Investigator: Deborah G Rund, MD Hadassah Medical Organization
  More Information

Responsible Party: Deborah Rund, Hadassah Medical Organization Identifier: NCT00159003     History of Changes
Other Study ID Numbers: 132910-HMO-CTIL
Study First Received: September 8, 2005
Last Updated: June 22, 2011

Keywords provided by Hadassah Medical Organization:
drug metabolism and disposition enzymes

Additional relevant MeSH terms:
Leukemia, Myeloid, Acute
Leukemia, Lymphoid
Leukemia, Lymphocytic, Chronic, B-Cell
Leukemia, Myeloid
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Disease Susceptibility
Neoplasms by Histologic Type
Lymphoproliferative Disorders
Lymphatic Diseases
Immunoproliferative Disorders
Immune System Diseases
Leukemia, B-Cell
Myeloproliferative Disorders
Bone Marrow Diseases
Hematologic Diseases
Disease Attributes
Pathologic Processes processed this record on April 28, 2017