WT1 Peptide Vaccination in Acute Myeloid Leukemia (AML)
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ClinicalTrials.gov Identifier: NCT00153582
Recruitment Status : Unknown
Verified September 2005 by Charite University, Berlin, Germany. Recruitment status was: Recruiting
In this trial, HLA-A2+ patients with active AML are vaccinated with a peptide from the leukemia-associated antigen WT1 together with immunological adjuvants keyhole limpet hemocyanin (KLH) as T-helper protein and granulocyte macrophage colony stimulating factor (GM-CSF) 4 times bi-weekly, then monthly.
Condition or disease
Acute Myeloid LeukemiaMyelodysplastic Syndrome
Biological: WT1 126-134 peptide
In this phase II trial HLA-A2+ patients with active AML without curative treatment option are vaccinated with WT1 126-134 peptide mixed with adjuvant KLH as T-helper protein and GM-CSF 4 times bi-weekly, then monthly.
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
AML or myelodysplastic syndromes (MDS)
Partial response (PR) or complete response (CR) or smoldering course without option for allogeneic stem cell transplantation