Pre-Emptive Analgesia Efficacy of Etoricoxib for Postoperative Pain
Taken together, studies of the value of pre-emptive analgesia are inconclusive. This randomized, double-blind, dose-ranging, placebo-controlled study was therefore designed to test that a reduction in post-operative morphine consumption can be achieved by a single-dose of etoricoxib before induction of anesthesia.
a Single-Dose of Etoricoxib
Post-Operative Morphine Consumption
Total Pain Relief Over 8 Hr(TOPAR8)
Post Transabdominal Hysterectomy
Drug: a single-dose of Etoricoxib before induction of anesthesia
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Primary Purpose: Treatment
|Official Title:||A Randomized, Double-Blind, Controlled Trial of Etoricoxib as a Pre-Emptive Analgesic for Abdominal Hysterectomy|
- The primary end points were morphine consumption within 24-hr post-operatively
- and total pain relief over 8 h (TOPAR8).
- Patient global response to therapy
|Study Start Date:||December 2004|
|Estimated Study Completion Date:||May 2005|
Patients undergoing transabdominal hysterectomy were randomized to a group taking a single dose (orally) of etoricoxib 120 mg (n = 18), etoricoxib 180 mg (n = 17) or placebo (n = 15) 2 hours before surgery under the same standardized general anesthesia. At the post-anesthetic care unit, intravenous morphine titration was given before starting self-controlled analgesia (PCA) device. Morphine consumption, pain relief score, sedative score, global evaluation score, and side-effects were recorded at 1, 2, 4, 8 and 24 h post-operatively. The primary end points were morphine consumption within 24-hr post-operatively and total pain relief over 8 h (TOPAR8). Patient global satisfaction was also assessed.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00149253
|KhonKaen University, KhonKaen, Thailand, 40002|
|Principal Investigator:||waraporn chau-in, Asso Prof.||Department of Anesthesiology, Faculty of Medicine,KhonKaen University,KhonKaen 40002, Thailand|