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The Specific Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00143468
Recruitment Status : Completed
First Posted : September 2, 2005
Last Update Posted : December 1, 2011
Sponsor:
Information provided by (Responsible Party):
Davide Chiumello, Policlinico Hospital

Brief Summary:
The investigators aim to study the specific elastance in ALI/ARDS patients during invasive mechanical ventilation.

Condition or disease Intervention/treatment Phase
Acute Lung Injury ARDS Behavioral: mechanical ventilation Not Applicable

Detailed Description:
In sedated and paralyzed ALI/ARDS patients, we studied the specific elastance and also, we compared the specific elastance to healthy subjects during invasive mechanical ventilation.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 100 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: The Specific Elastance in Acute Lung Injury/Acute Respiratory Distress Syndrome (ALI/ARDS) Patients: Barotrauma and Volutrauma
Study Start Date : March 2005
Actual Primary Completion Date : March 2007
Actual Study Completion Date : May 2008


Arm Intervention/treatment
Experimental: 1
ALI/ARDS patients and healthy subjects
Behavioral: mechanical ventilation
measurement of specific lung elastance during mechanical ventilation




Primary Outcome Measures :
  1. Specific elastance [ Time Frame: 5 minutes ]


Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years to 90 Years   (Child, Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Stable ALI/ARDS patients during invasive mechanical ventilation

Exclusion Criteria:

  • Hemodynamic failure, pneumothorax

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00143468


Locations
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Italy
Ospedale policlinico
Milano, Italy, 20122
Sponsors and Collaborators
Policlinico Hospital
Investigators
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Principal Investigator: davide chiumello, MD Policlinico Hospital
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: Davide Chiumello, MD, Policlinico Hospital
ClinicalTrials.gov Identifier: NCT00143468    
Other Study ID Numbers: 1160
First Posted: September 2, 2005    Key Record Dates
Last Update Posted: December 1, 2011
Last Verified: November 2011
Keywords provided by Davide Chiumello, Policlinico Hospital:
gas exchange
respiratory mechanics
Additional relevant MeSH terms:
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Respiratory Distress Syndrome
Respiratory Distress Syndrome, Newborn
Acute Lung Injury
Lung Injury
Wounds and Injuries
Lung Diseases
Respiratory Tract Diseases
Respiration Disorders
Infant, Premature, Diseases
Infant, Newborn, Diseases
Thoracic Injuries