High Frequency Stimulation of the GPi or Thalamus in Tourette's Syndrome
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ClinicalTrials.gov Identifier: NCT00139308
Recruitment Status :
First Posted : August 31, 2005
Last Update Posted : August 31, 2005
Groupe Hospitalier Pitie-Salpetriere
Institut National de la Santé Et de la Recherche Médicale, France
Tourette's syndrome is a disabling neuropsychiatric disorder with major psychosocial consequences in some patients. The pathophysiology is still unknown. Some data suggest an dysfunction of limbic circuits in basal ganglia. The aim of this study is to evaluate the effect of high frequency stimulation of the internal part of the globus pallidus and/or parafascicular-median centre of the thalamus, two structures implicated in the limbic circuit, in patients with severe Tourette's syndrome.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 55 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Tourette's syndrome (DSM IV)
inducing a disability in the social and personal life