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Brain Reaction to Treatment of Nicotine Dependence

This study has been completed.
Information provided by (Responsible Party):
VA Office of Research and Development Identifier:
First received: April 14, 2005
Last updated: April 5, 2013
Last verified: April 2013

The purpose of the study was to determine how the treatments for cigarette craving work.

Hypothesis: During exposure to cigarette-related cues, heavy smokers will have greater reductions in regional brain activation from before to after both forms of active treatments than from before to after placebo.

Condition Intervention Phase
Nicotine Dependence
Drug: Zyban
Phase 1

Study Type: Interventional
Study Design: Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Official Title: Neural Substrates of Treatment for Nicotine Dependence

Resource links provided by NLM:

Further study details as provided by VA Office of Research and Development:

Primary Outcome Measures:
  • 2-FA PET scan results [ Time Frame: Within the first few weeks of study initiation ]
    Brain activity and activation in response to cigarette-related cues

Enrollment: 104
Study Start Date: October 2002
Study Completion Date: June 2011
Primary Completion Date: April 2007 (Final data collection date for primary outcome measure)

Detailed Description:
PET and fMRI scanning were used to examine brain activity and activation in cigarette smokers in response to cigarette-related cues.

Ages Eligible for Study:   21 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Heavy smoker, more than one pack per day
  • Free of medical conditions or medications that affect brain activity
  • Not pregnant

Exclusion Criteria:

Drug or alcohol dependence Mental Illness Pregnancy Medications that affect brain function Unstable medical conditions

  Contacts and Locations
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Please refer to this study by its identifier: NCT00108173

United States, California
VA Greater Los Angeles Healthcare System, West LA
West Los Angeles, California, United States, 90073
Sponsors and Collaborators
VA Office of Research and Development
Principal Investigator: Arthur L. Brody, MD VA Greater Los Angeles Healthcare System, West LA
  More Information

Responsible Party: VA Office of Research and Development Identifier: NCT00108173     History of Changes
Other Study ID Numbers: ADRD-018-02S
Study First Received: April 14, 2005
Last Updated: April 5, 2013

Keywords provided by VA Office of Research and Development:
Position Emission Tomography (PET)
Nicotine dependence
functional magnetic resonance imaging
cigarette cues

Additional relevant MeSH terms:
Tobacco Use Disorder
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Ganglionic Stimulants
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Nicotinic Agonists
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action processed this record on May 22, 2017