Neuromodulation and Language Acquisition (Stage Ib)
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The purpose of this study is to determine whether rivastigmine or pramipexol are effective in boosting semantic language acquisition in healthy subjects.
Condition or disease
Drug: PramipexoleDrug: Rivastigmine
Our prior work shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind clinical trial, we probe whether a selective d2/d3 dopamine agonist (pramipexole) or cholinergic neuromodulation (rivastigmine), after a titration period of five days, will yield a learning enhancement comparable to using levodopa in healthy subjects. The expected scientific results will strengthen the basis for transferring neuromodulatory interventions from the laboratory to stroke patients with language dysfunctions.
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Ages Eligible for Study:
20 Years to 35 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
20-35 years old
Left language dominance (as assessed by functional transcranial Doppler ultrasonography [fTCD])