A Study of Motexafin Gadolinium (MGd) in Combination With Docetaxel and Cisplatin for Treatment of Non-Small Cell Lung Cancer (NSCLC)
|ClinicalTrials.gov Identifier: NCT00102505|
Recruitment Status : Completed
First Posted : January 31, 2005
Last Update Posted : April 3, 2009
The purpose of the study is to determine the dose limiting toxicities and maximum tolerated dose of motexafin gadolinium when administered with docetaxel and cisplatin in patients with Non-small Cell Lung Cancer.
A cycle consists of 3 weeks. During week 1, patients receive MGd, docetaxel, and cisplatin treatment followed by 2 weeks without treatment.
Eligible patients will receive 1 or 2 doses of MGd, depending on cohort, and a single dose of docetaxel and cisplatin at 75 mg/m² during the first week of each cycle. Additionally, tumor response will be evaluated at the end of even numbered cycles (2, 4, and 6). Patients may stay on the study a maximum of 6 cycles.
|Condition or disease||Intervention/treatment||Phase|
|Non-Small-Cell Lung Carcinoma Carcinoma, Bronchogenic||Drug: Motexafin Gadolinium Injection||Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||36 participants|
|Masking:||None (Open Label)|
|Official Title:||Phase I Trial of Motexafin Gadolinium (MGd) in Combination With Docetaxel and Cisplatin for Treatment of Non-Small Cell Lung Cancer (NSCLC)|
|Study Start Date :||November 2004|
- Dose limiting toxicities of MGd when administered concurrently with docetaxel and cisplatin
- Maximum tolerated dose of MGd when administered concurrently with docetaxel and cisplatin
- Tumor response
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00102505
|United States, Texas|
|The University of Texas MD Anderson Cancer Center|
|Houston, Texas, United States, 77030|