This site became the new on June 19th. Learn more.
Show more Menu IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu IMPORTANT: Talk with a trusted healthcare professional before volunteering for a study. Read more... Menu
Give us feedback

Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome

This study has been completed.
Information provided by:
VA Office of Research and Development Identifier:
First received: December 30, 2004
Last updated: January 20, 2009
Last verified: December 2004
The purpose of this study is to provide new information and to determine which kinds of brief, tolerable, experimental pain are affected by the drugs being studied in patients with irritable bowel syndrome, a disease that causes chronic abdominal pain. The effects of dextromethorphan, naloxone, and fentanyl on experimental pain stimuli will be tested in these studies to better understand what causes irritable bowel syndrome.

Condition Intervention
Irritable Bowel Syndrome Procedure: Viceral Perception Testing

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Double
Primary Purpose: Diagnostic
Official Title: Central Nervous System Modulation of Visceral Pain in Persian Gulf War Syndrome

Further study details as provided by VA Office of Research and Development:

Study Start Date: September 2000

Ages Eligible for Study:   18 Years to 72 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
  • Patients with irritable bowel syndrome and healthy pain-free individuals (as controls) will be studied.
  • No medical condition that would contraindicate use of dextromethorphan, fentanyl or naloxone.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00100425

United States, Florida
Malcolm Randall VA Medical Center
Gainesville, Florida, United States, 32608
Sponsors and Collaborators
VA Office of Research and Development
  More Information Identifier: NCT00100425     History of Changes
Other Study ID Numbers: CADE-ARCD2
Study First Received: December 30, 2004
Last Updated: January 20, 2009

Keywords provided by VA Office of Research and Development:
Irritable Bowel Syndrome
Visceral Hypersensitivity
Visceral Pain

Additional relevant MeSH terms:
Irritable Bowel Syndrome
Visceral Pain
Pathologic Processes
Colonic Diseases, Functional
Colonic Diseases
Intestinal Diseases
Gastrointestinal Diseases
Digestive System Diseases
Nociceptive Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on August 22, 2017