Enhancing the Outcome of Skills Training for People With Schizophrenia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00069433
Recruitment Status : Completed
First Posted : October 9, 2003
Last Update Posted : September 24, 2013
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
New York State Psychiatric Institute

Brief Summary:
This study will determine the effectiveness of skills training in people with schizophrenia and the applicability of the acquired skills in the "real world."

Condition or disease Intervention/treatment Phase
Schizophrenia Procedure: Social skills and symptom management training Not Applicable

Detailed Description:

People with schizophrenia have a large number of social and symptom management training programs available to them. Studies suggest that these training programs are effective, but their generalizability and effectiveness in outpatient settings has not been thoroughly examined. This study will examine the treatment outcomes of a skills training approach in schizophrenic individuals taking antipsychotic medication.

Participants taking stable doses of risperidone, olanzapine, or quetiapine will be randomly assigned to receive either intensive symptom management and social skills training or group therapy for 12 months. A verbal memory test will be used to stratify the randomization procedure and to control for neurocognitive functioning.

Study Type : Interventional  (Clinical Trial)
Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Skills Training for Schizophrenia: Enhancing Outcomes
Study Start Date : April 2001
Actual Primary Completion Date : November 2005
Actual Study Completion Date : November 2005

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Schizophrenia

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Diagnosis of schizophrenia or schizoaffective disorder for > 5 years
  • Use of stable dose risperidone, olanzapine, or quetiapine for at least 1 month with no planned medication changes
  • Social Behavior Scale (SBS) score > 45
  • Willing and able to provide informed consent

Exclusion Criteria:

  • Intelligence Quotient < 70
  • Use of more than one antipsychotic medication
  • Use of benzodiazepines, tricyclic antidepressants, or anticholinergic medication commonly used to treat extrapyramidal symptoms
  • Diagnostic and Statistical Manual (DSM)-IV criteria for alcohol or other substance dependence
  • History of any traumatic brain injury leading to loss of consciousness for > 30 minutes
  • Diagnosis of a comorbid medical condition that could interfere with antipsychotic medication treatment or the ability to complete the study

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00069433

United States, Connecticut
Hall-Brooke-The Center
Bridgeport, Connecticut, United States, 06606
Hall-Brooke Behavioral Health Services
Westport, Connecticut, United States, 06880
Sponsors and Collaborators
New York State Psychiatric Institute
National Institute of Mental Health (NIMH)

Responsible Party: New York State Psychiatric Institute Identifier: NCT00069433     History of Changes
Other Study ID Numbers: #4339
R01MH066362 ( U.S. NIH Grant/Contract )
First Posted: October 9, 2003    Key Record Dates
Last Update Posted: September 24, 2013
Last Verified: September 2013

Keywords provided by New York State Psychiatric Institute:
Psychotic Disorders

Additional relevant MeSH terms:
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders