Treating Thought Problems in Patients With Schizophrenia
|ClinicalTrials.gov Identifier: NCT00051740|
Recruitment Status : Completed
First Posted : January 17, 2003
Last Update Posted : April 9, 2013
|Condition or disease||Intervention/treatment||Phase|
|Schizophrenia||Behavioral: Cognitive Adaptation Therapy (CAT) Behavioral: Minimal Environmental Supports (MES)||Not Applicable|
Many schizophrenia patients have serious difficulties that affect their quality of life. Cognitive Adaptation Training (CAT) may improve adaptive functioning, quality of life, and rates of relapse in schizophrenia patients. CAT, which involves compensatory strategies or environmental supports, is tailored to each individual and is based on executive functioning levels and other factors.
Participants are randomly assigned to CAT, Minimal Environmental Supports (MES), or treatment as usual for 2 years. Participants receiving CAT will have a trained therapist make weekly visits to their home for 9 months. Over the following 3 months, the frequency of CAT visits will be slowly reduced to once a month. For the remaining 12 months of treatment, patients receive CAT only once a month.
Participants assigned to the MES group receive a generic set of supplies and equipment (calendar, alarm clock, watch, bus passes, etc.) at the beginning of the 2-year period. Each month, the supplies are replenished as necessary during the patient's scheduled clinic visit.
In all groups, assessments of adaptive function and quality of life occur at study start and at 3, 6, 9, 18, and 24 months.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||120 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Compensating for Cognitive Deficits in Schizophrenia|
|Study Start Date :||February 2002|
|Actual Primary Completion Date :||October 2008|
|Actual Study Completion Date :||October 2008|
Active Comparator: Cognitive Adaptation Therapy
Subjects receive Cognitive adaptation therapy as part of treatment for schizophrenia
|Behavioral: Cognitive Adaptation Therapy (CAT)|
Active Comparator: Minimal Environmental Support
Subjects receive minimal environmental support in schizophrenia treatment
|Behavioral: Minimal Environmental Supports (MES)|
- Primary [ Time Frame: up to 24 months ]compare Cognitive Adaptation Training (CAT) to minimal schizophrenia treatment.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00051740
|United States, Texas|
|University of Texas Health Science Center at San Antonio|
|San Antonio, Texas, United States, 78229|
|Principal Investigator:||Dawn I. Velligan, Ph.D.||The University of Texas Health Science Center at San Antonio|