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Treating Thought Problems in Patients With Schizophrenia

This study has been completed.
Information provided by (Responsible Party):
Dawn Velligan, The University of Texas Health Science Center at San Antonio Identifier:
First received: January 15, 2003
Last updated: April 5, 2013
Last verified: April 2013
This study will compare Cognitive Adaptation Training (CAT) to minimal schizophrenia treatment. This study will also determine whether the intensity of CAT can be reduced and still provide benefits to patients with schizophrenia.

Condition Intervention
Behavioral: Cognitive Adaptation Therapy (CAT)
Behavioral: Minimal Environmental Supports (MES)

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Participant)
Primary Purpose: Treatment
Official Title: Compensating for Cognitive Deficits in Schizophrenia

Resource links provided by NLM:

Further study details as provided by Dawn Velligan, The University of Texas Health Science Center at San Antonio:

Primary Outcome Measures:
  • Primary [ Time Frame: up to 24 months ]
    compare Cognitive Adaptation Training (CAT) to minimal schizophrenia treatment.

Estimated Enrollment: 120
Study Start Date: February 2002
Study Completion Date: October 2008
Primary Completion Date: October 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Cognitive Adaptation Therapy
Subjects receive Cognitive adaptation therapy as part of treatment for schizophrenia
Behavioral: Cognitive Adaptation Therapy (CAT)
Active Comparator: Minimal Environmental Support
Subjects receive minimal environmental support in schizophrenia treatment
Behavioral: Minimal Environmental Supports (MES)

Detailed Description:

Many schizophrenia patients have serious difficulties that affect their quality of life. Cognitive Adaptation Training (CAT) may improve adaptive functioning, quality of life, and rates of relapse in schizophrenia patients. CAT, which involves compensatory strategies or environmental supports, is tailored to each individual and is based on executive functioning levels and other factors.

Participants are randomly assigned to CAT, Minimal Environmental Supports (MES), or treatment as usual for 2 years. Participants receiving CAT will have a trained therapist make weekly visits to their home for 9 months. Over the following 3 months, the frequency of CAT visits will be slowly reduced to once a month. For the remaining 12 months of treatment, patients receive CAT only once a month.

Participants assigned to the MES group receive a generic set of supplies and equipment (calendar, alarm clock, watch, bus passes, etc.) at the beginning of the 2-year period. Each month, the supplies are replenished as necessary during the patient's scheduled clinic visit.

In all groups, assessments of adaptive function and quality of life occur at study start and at 3, 6, 9, 18, and 24 months.


Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • DSM-IV diagnosis of schizophrenia or schizoaffective disorder
  • Treatment with an atypical antipsychotic medication
  • Stable living environment
  • Able to read, understand, and complete rating scales and neuropsychological testing
  • Willing to participate in psychosocial treatments for schizophrenia that may involve home visits

Exclusion Criteria:

  • History of significant head trauma, seizure disorder, or mental retardation
  • Alcohol or drug abuse that could interfere with participation in the study
  • Treatment by an ACT team
  • History of violence in the past year
  • Score > 80 on the SOFAS
  • Hospitalized in the past year
  Contacts and Locations
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Please refer to this study by its identifier: NCT00051740

United States, Texas
University of Texas Health Science Center at San Antonio
San Antonio, Texas, United States, 78229
Sponsors and Collaborators
The University of Texas Health Science Center at San Antonio
Principal Investigator: Dawn I. Velligan, Ph.D. The University of Texas Health Science Center at San Antonio
  More Information

Responsible Party: Dawn Velligan, Clinical Professor Department of Psychiatry, The University of Texas Health Science Center at San Antonio Identifier: NCT00051740     History of Changes
Other Study ID Numbers: R01MH061775 ( US NIH Grant/Contract Award Number )
Study First Received: January 15, 2003
Last Updated: April 5, 2013

Additional relevant MeSH terms:
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders processed this record on May 25, 2017