Natural History of Anthrax: a Study of Primary Infected, Recovered, and Exposed Individuals (SPoRE); and Evaluation of AVA-Vaccinated Recipients
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|ClinicalTrials.gov Identifier: NCT00050310|
Recruitment Status : Recruiting
First Posted : December 4, 2002
Last Update Posted : December 14, 2020
This study will examine pathophysiology and immune response of anthrax in infected or exposed individuals to learn more about the disease symptoms, prevention and response to treatment. In addition, it will evaluate immune response to the anthrax vaccine AVA (Anthrax Vaccine Adsorbed) in healthy, non-infected individuals.
The following individuals may be eligible for this study:
- People with confirmed or suspected anthrax (inhalational, cutaneous or gastrointestinal, either acute or recovering);
- People exposed to anthrax who have no clinical symptoms.
- Healthy people who have not been exposed to anthrax and have been vaccinated with AVA.
Those enrolled in the study will undergo the following tests and procedures.
Infected and exposed individuals:
- Symptomatic participants will have the following clinical procedures if medically necessary:
- a) blood tests for cell counts, chemistries and evidence of anthrax bacteria;
- b) nasal swab to test for evidence of anthrax
- c) chest X-ray;
- d) computed tomography (CT) scan (special X-rays to examine the lungs or abdomen);
- e) echocardiogram to examine the heart
- f) magnetic resonance imaging (MRI), a special imaging test using a magnetic field and radio waves to examine the infected area of skin and soft tissue for patients with cutaneous anthrax.
- All subjects (with or without symptoms) will have the following research procedures:
- a) blood tests to examine immune response to anthrax;
- b) throat swab to test for evidence of anthrax
- c) nasopharyngeal wash to test for anthrax. Water is sprayed into the nostrils and then allowed to drain for collection in a cup;
- d) induced sputum to test for presence of and immune response to anthrax. A mask with a saline mist is placed over the subject s mouth and nose, causing the subject to cough and produce sputum from the lungs. The sputum is collected in a cup this is for individuals 18 and older who do not undergo bronchoscopy, described below.
- Participants 18 years of age and older may have the following optional research procedures:
- a) leukapheresis or plasmapheresis (see description under non-infected, vaccinated individuals above);
- b) lymph node biopsy. A sample of lymph node tissue is surgically removed under local anesthetic;
- c) bronchoalveolar lavage. This 15- to 30-minute procedure is done in the intensive care unit. The mouth, nasal passages, throat and airways are numbed with lidocaine and a thin flexible tube is passed through the nose into the lung airways. Samples of cells and secretions are obtained by rinsing (lavage) the airways with salt water. The fluid is analyzed for infection, inflammatory cells and inflammatory chemicals.
All infected and exposed individuals will have periodic medical history and physical exam evaluations and be offered treatment or prophylaxis (treatment to prevent infection) with antibiotics, according to the guidelines of the Centers for Disease Control and Prevention (CDC). Patients will be monitored for at least 24 months after antibiotic treatment, or longer if circumstances warrant.
Non-infected, vaccinated individuals
- medical history and physical examination
- blood tests-- between 10 and 50 ml (2-10 teaspoons) of blood will be drawn at a time, and not more than 450 ml will be taken in a 6-week period. Based on the blood test results, other optional research procedures may be requested
- leukapheresis to collect white blood cells and plasmapheresis to collect plasma (the liquid part of the blood). For both of these procedures, blood is collected through a needle placed in an arm vein. The blood flows into a special machine that separates it into its components by spinning. The desired components (white cells or plasma) are removed and the rest of the blood is returned to the body through the same needle or a second needle in the other arm.
|Condition or disease|
|Anthrax Bacillus Infections|
|Study Type :||Observational|
|Estimated Enrollment :||200 participants|
|Official Title:||Natural History of Anthrax: A Study of Primary Infected, Recovered, and Exposed (SPoRE) Individuals and Evaluation of AVA Vaccinated Recipients|
|Actual Study Start Date :||November 7, 2002|
adults and children with acute anthrax infection
AVA Recipient/Healthy Volunteer
healthy adults who have received AVA vaccine
adults and children in recovering phase of anthrax infection
adults and children with suspected exposure to anthrax
- evaluate the natural history of anthrax and immune responseto anthrax antigens over time [ Time Frame: 2 years ]This study is intended to evaluate the natural history of anthrax and the immune response to anthrax antigens over time in four subpopulations of men, women and children with:--acute infection (confirmed or suspected)--recovering phase of infection--exposure to infection--no known or no exposure to infection but a history of anthrax vaccination (AVA) (since no children have received AVA, they will beexcluded from this subgroup)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00050310
|Contact: Rosemary McConnell, R.N.||(301) firstname.lastname@example.org|
|Contact: Mary E Wright, M.D.||(301) email@example.com|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 firstname.lastname@example.org|
|Principal Investigator:||Mary E Wright, M.D.||National Institute of Allergy and Infectious Diseases (NIAID)|