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Ondansetron for the Treatment of Methamphetamine Dependence - 1

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ClinicalTrials.gov Identifier: NCT00040053
Recruitment Status : Completed
First Posted : June 18, 2002
Last Update Posted : January 12, 2017
University of Texas
Information provided by:
National Institute on Drug Abuse (NIDA)

Brief Summary:
The purpose of this study is to assess ondansetron for the treatment of methamphetamine dependence.

Condition or disease Intervention/treatment Phase
Amphetamine-Related Disorders Drug: Ondansetron Phase 2

Detailed Description:
This study was designed to be a preliminary assessment of the efficacy and safety of 3-wide range doses of ondansetron (0.25, 1.0 and 4.0 mg taken orally twice per day) to reduce methamphetamine use in subjects with methamphetamine dependence and to determine the optimal dose of ondansetron.

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Study Type : Interventional  (Clinical Trial)
Enrollment : 154 participants
Allocation: Randomized
Masking: Double
Primary Purpose: Treatment
Official Title: Double-Blind, Placebo-Controlled, Dose Response Trial of Ondansetron for the Treatment of Methamphetamine Dependence.
Study Start Date : June 2002
Actual Study Completion Date : February 2004

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Methamphetamine

Primary Outcome Measures :
  1. Clinicial improvement

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 99 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

18 years of age. Treatment seeking for meth dependence.

Exclusion Criteria:

Please contact site director for more details.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00040053

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United States, California
South Bay Treatment Center
Chula Vista, California, United States, 91911
Matrix Institute on Addictions
Costa Mesa, California, United States, 92627
United States, Hawaii
John A. Burns School of Medicine
Honolulu, Hawaii, United States, 96813
United States, Iowa
Powell Chemical Dependency Center
Des Moines, Iowa, United States, 50316
United States, Missouri
University of Missouri - Kansas City
Kansas City, Missouri, United States, 64108
United States, Texas
University of Texas Health Science Center
Houston, Texas, United States, 77225
Sponsors and Collaborators
National Institute on Drug Abuse (NIDA)
University of Texas
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Principal Investigator: Thomas Newton, M.D. National Institute on Drug Abuse (NIDA)
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ClinicalTrials.gov Identifier: NCT00040053    
Other Study ID Numbers: NIDA-CTO-0011-1
First Posted: June 18, 2002    Key Record Dates
Last Update Posted: January 12, 2017
Last Verified: July 2008
Keywords provided by National Institute on Drug Abuse (NIDA):
amphetamine dependence
Additional relevant MeSH terms:
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Amphetamine-Related Disorders
Substance-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Gastrointestinal Agents
Dermatologic Agents
Serotonin Antagonists
Serotonin Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Antipsychotic Agents
Tranquilizing Agents
Central Nervous System Depressants
Psychotropic Drugs
Anti-Anxiety Agents