Nuclear Magnetic Spectroscopy Imaging to Evaluate Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis
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ClinicalTrials.gov Identifier: NCT00023075 |
Recruitment Status :
Completed
First Posted : August 23, 2001
Last Update Posted : March 4, 2008
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This study will use a magnetic resonance imaging technique called nuclear magnetic spectroscopy (H-MRS) to define the pathology and progression of primary lateral sclerosis, hereditary spastic paraplegia and amyotrophic lateral sclerosis and assess the usefulness of this technique in evaluating patients' response to therapy. H-MRS will be used to examine metabolic changes in the parts of the brain and spinal cord (motor cortex and corticospinal tract) involved in movement.
Normal volunteers and patients with primary lateral sclerosis, hereditary spastic paraplegia or amyotrophic lateral sclerosis between 21 and 65 years of age may be eligible for this study. Participants will have up to five H-MRS studies, including baseline and follow-up tests. For this procedure, the subject lies on a stretcher that is moved into a strong magnetic field. Earplugs are worn to muffle the loud knocking noise that occurs during switching of radio frequencies. The subject will be asked to lie still during each scan, for 1 to 8 minutes at a time. Total scanning time varies from 20 minutes to 2 hours, with most examinations lasting between 45 and 90 minutes. Communication with the medical staff is possible at all times during the scan.
Condition or disease |
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Primary Lateral Sclerosis Hereditary Spastic Paraplegia Amyotrophic Lateral Sclerosis |
Study Type : | Observational |
Enrollment : | 55 participants |
Official Title: | Nuclear Magnetic Spectroscopy for the Evaluation of Primary Lateral Sclerosis, Hereditary Spastic Paraplegia and Amyotrophic Lateral Sclerosis |
Study Start Date : | August 2001 |
Study Completion Date : | August 2003 |


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Ages Eligible for Study: | Child, Adult, Older Adult |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
INCLUSION CRITERIA:
Adult patients with PLS, HSP, and ALS already evaluated by protocol #01-N-0148.
Adult normal volunteers
EXCLUSION CRITERIA:
Pregnancy, implanted devices such as pacemakers, medication pumps or defibrillators, metal in the cranium except the mouth, intracardiac lines, history of eye shrapnel injury or any other condition/device that may contraindicate or prevent the acquisition of an MRI.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00023075
United States, Maryland | |
National Institute of Neurological Disorders and Stroke (NINDS) | |
Bethesda, Maryland, United States, 20892 |
ClinicalTrials.gov Identifier: | NCT00023075 |
Other Study ID Numbers: |
010241 01-N-0241 |
First Posted: | August 23, 2001 Key Record Dates |
Last Update Posted: | March 4, 2008 |
Last Verified: | August 2003 |
MRI Neuromuscular Disease N-Acetyl Aspartate Choline Creatine Spasms Spasticity |
Primary Lateral Sclerosis Hereditary Spastic Paraplegia Spastic Paraparesis Healthy Volunteer HV Normal Control |
Muscle Spasticity Motor Neuron Disease Amyotrophic Lateral Sclerosis Paraplegia Spastic Paraplegia, Hereditary Sclerosis Pathologic Processes Neurodegenerative Diseases Nervous System Diseases Neuromuscular Diseases Spinal Cord Diseases Central Nervous System Diseases TDP-43 Proteinopathies Proteostasis Deficiencies |
Metabolic Diseases Muscular Diseases Musculoskeletal Diseases Muscle Hypertonia Neuromuscular Manifestations Neurologic Manifestations Paralysis Hereditary Sensory and Motor Neuropathy Nervous System Malformations Heredodegenerative Disorders, Nervous System Polyneuropathies Peripheral Nervous System Diseases Congenital Abnormalities Genetic Diseases, Inborn |